| In vitro | Melittin Acetate is an immunologically related PLA2 stimulating peptide from bee venom. Melittin Acetate increases the activity of the high molecular weight enzyme[1]. Melittin Acetate is a cytotoxic peptide from bee venom. Melittin Acetate shows toxicity against both A2780CR and A2780 cells, with IC50 values of 4.5 and 6.8 μg/mL, respectively. Melittin Acetate shows natural anti-bacterial, anti-viral, and anti-inflammatory properties. It has also been shown to have diverse anticancer effects in several different cancer cell lines including those of gastric, breast, ovarian, liver, prostate, cervical, and lung origins. The mechanisms by which Melittin Acetate, an amphipathic haemolytic peptide, exerts its potential anticancer effects include inhibition of cell proliferation, induction of apoptosis, and direct necrosis. Melittin Acetate can also prevent EGF-induced cell invasion through its inhibition of the PI3K/Akt/mTOR signaling pathway, but this is primarily related to breast cancer cells[2]. |
United States
