| Name | Melanin Concentrating Hormone, salmon acetate |
| Description | Melanin Concentrating Hormone, salmon acetate (MCH (salmon)) is a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. |
| In vitro | An orphan G protein-coupled receptor (SLC-1/GPR24) has been identified as a receptor for MCH (MCHR1). MCHR2 has higher protein sequence homology to MCHR1 than any other G protein-coupled receptor. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein[1]. |
| In vivo | Melanin Concentrating Hormone stimulates appetite. Continuous infusion of Melanin Concentrating Hormone into the ventricular system increases food intake for 7-8 days[2]. Intracerebroventricular infusion of Melanin Concentrating Hormone (10 μg/day) causes a slight but significant increase in body weight in mice maintained on the regular diet. Chronic stimulation of the brain Melanin Concentrating Hormone system could cause obesity in mice[3]. |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | SLC-1/GPR24 | salmon | MelaninconcentratingHormoneReceptor(MCHR) | MelaninconcentratingHormoneReceptor | Melaninconcentrating Hormone Receptor (MCHR) | Melanin-concentrating Hormone Receptor | Melanin Concentrating Hormone, salmon acetate | Melanin Concentrating Hormone, salmon Acetate | MCHR2 | MCHR | MCH |
| Inhibitors Related | MCH(human, mouse, rat) | MCHR1 antagonist 2 | ATC 0175 hydrochloride | SNAP 94847 | Neuropeptide EI, rat acetate | PG 931 acetate | TC-MCH 7c | SNAP 94847 hydrochloride | GW-803430 | [Ala17]-MCH acetate |
| Related Compound Libraries | Peptide Compound Library |