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ChemicalBook Product Catalog Maritoclax

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Maritoclax NEW

$38.00 1mg

$54.00 2mg

$89.00 5mg

Min. Order
Purity99.87%
Cas No1227962-62-0
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Maritoclax
CAS No	1227962-62-0
EC-No
Min. Order
Purity	99.87%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Maritoclax
Description	Maritoclax (Marinopyrrole A) (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor, shows >8 fold selectivity than BCL-xl (IC50 > 80 μM),with an IC50 value of 10.1 μM.
In vitro	Maritoclax (Marinopyrrole A) (3 µM) induces cell death associated with MCL1 decrease and translation inhibition. It dephosphorylates EIF4EBP1 while reducing EIF4E phosphorylation[3]. Maritoclax is significantly more effective against Bcl-2-dependent RS4;11 cells (IC50: 2 µM) compared to Mcl-1-dependent HeLa cells (IC50: 20 µM)[4]. It blocks Bim BH3 α-helix binding to Mcl-1 but not Bcl-XL, and markedly inhibits the viability of Mcl-1-IRES-BimEL cells (EC50=1.6 µM) with over 40-fold selectivity compared to Bcl-2-IRES-BimEL (EC50=65.1 µM) and Bcl-XL-IRES-BimEL (EC50=70.0 µM) cells. Maritoclax selectively induces cell death in Mcl-1-dependent leukemia cells and causes proteasome-mediated Mcl-1 degradation without inducing Mcl-1 phosphorylation or Noxa expression. It inhibits Mcl-1 interaction with Bim in intact cells, triggers cytochrome c release from isolated mitochondria, and synergistically sensitizes lymphoma/leukemia cells to ABT-737[1]. Maritoclax is active against all tested S. aureus strains, including glycopeptide-intermediate and vancomycin-resistant MRSA, and has potent activity against other Gram-positive organisms, and H. influenzae but is inactive against tested Gram-negative strains. It shows substantial concentration-dependent killing against MRSA strain TCH1516 and acts more rapidly than vancomycin or linezolid. Maritoclax exhibits a favorable therapeutic index with IC50 values exceeding 20× above the MIC: 32–64 µg/mL against HeLa cells and 8–32 µg/mL against L929 cells[2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 43 mg/mL (84.29 mM)
Keywords	Inhibitor \| Bcl-2 Family \| inhibit \| Maritoclax
Inhibitors Related	Gossypol (acetic acid) \| (S)-(+)-Ibuprofen \| Allethrin \| Navitoclax \| Docetaxel trihydrate \| Gossypol \| Triacetylresveratrol \| Diphenyl disulfide \| Lisaftoclax \| Venetoclax \| (E)-Ferulic acid \| Thymoquinone
Related Compound Libraries	Cuproptosis Compound Library \| Apoptosis Compound Library \| Bioactive Compound Library \| Hematonosis Compound Library \| Inhibitor Library \| NO PAINS Compound Library \| Anti-Aging Compound Library \| Bioactive Compounds Library Max \| Covalent Inhibitor Library \| Anti-Cancer Compound Library

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