| Name | Marein |
| Description | Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy. |
| In vitro | To clarify whether Marein, a major compound from the hypoglycemic plant Coreopsis tinctoria, prevents PC12 cell damage induced by MG, we cultured PC12 cells in the presence of MG and Marein. Marein attenuated MG-induced changes in the mitochondrial membrane potential (ΔΨm), mitochondrial permeability transition pores (mPTPs), intracellular Ca2+ levels, the production of reactive oxygen species (ROS), glutathione (GSH)/glutathione disulfide (GSSG) and adenosine triphosphate (ATP), and the increase in the percentage of apoptotic cells. Marein also increased glyoxalase I (Glo1) activity, phospho-AMPKα± (Thr172) and Bcl-2 expression and diminished the activation of Bax, caspase-3 and inhibitor of caspase-activated deoxyribonuclease (ICAD). Importantly, pretreatment of cells with Marein diminished the compound C-induced inactivation of p-AMPK. Molecular docking simulation showed that Marein interacted with the γ subunit of AMPK[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 60 mg/mL (133.22 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.44 mM), Sonication is recommended.
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| Keywords | neuroprotective | Marein | IRS | Inhibitor | inhibit | Histone deacetylases | HDAC | GSK-3β | glycoside | GLUT1 | GLUT | FoxO1 | CaMKK | antioxidative | antihypertensive | antihyperlipidemic | antidiabetic | AMPK | AMP-activated protein kinase | Akt |
| Inhibitors Related | Aceglutamide | Methoxyacetic acid | Sodium 4-phenylbutyrate | Hyaluronic acid | Manganese chloride (tetrahydrate) | Curcumin | Valproic Acid | Ethyl linoleate | Sodium butanoate | Methyl eugenol | 2,3-Butanediol | Chitosan oligosaccharide |
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