| 名称 | Marein |
| 描述 | Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic encephalopathy. |
| 体外活性 | To clarify whether Marein, a major compound from the hypoglycemic plant Coreopsis tinctoria, prevents PC12 cell damage induced by MG, we cultured PC12 cells in the presence of MG and Marein. Marein attenuated MG-induced changes in the mitochondrial membrane potential (ΔΨm), mitochondrial permeability transition pores (mPTPs), intracellular Ca2+ levels, the production of reactive oxygen species (ROS), glutathione (GSH)/glutathione disulfide (GSSG) and adenosine triphosphate (ATP), and the increase in the percentage of apoptotic cells. Marein also increased glyoxalase I (Glo1) activity, phospho-AMPKα± (Thr172) and Bcl-2 expression and diminished the activation of Bax, caspase-3 and inhibitor of caspase-activated deoxyribonuclease (ICAD). Importantly, pretreatment of cells with Marein diminished the compound C-induced inactivation of p-AMPK. Molecular docking simulation showed that Marein interacted with the γ subunit of AMPK[1] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/ml (133.21 mM)
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| 关键字 | GLUT1 | HDAC | Inhibitor | Marein | Akt | inhibit | antioxidative | Histone deacetylases | antihypertensive | AMP-activated protein kinase | IRS | glycoside | antihyperlipidemic | AMPK | antidiabetic | GSK-3β | FoxO1 | neuroprotective | CaMKK |
| 相关产品 | Valproic acid sodium salt | Panobinostat | Sodium 4-phenylbutyrate | Adenosine monophosphate | Valproic Acid | Curcumin | Artemisinin | Methyl cinnamate | Metformin hydrochloride | 2,3-Butanediol | Chitosan oligosaccharide | 4-Phenylbutyric acid |
| 相关库 | 抗癌天然产物库 | 中药单体化合物库 | 经典已知活性库 | 激酶抑制剂库 | 植物来源化合物库 | 天然产物库 | 神经保护化合物库 | 高通量筛选天然产物库 | 抗衰老化合物库 | 已知活性化合物库 |
United States
