| Name | Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD |
| Description | Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (PF-05231023) is a long-acting fibroblast growth factor 21 (FGF21) analog and FGF21-receptor agonist, suitable for development as a potential treatment for T2DM. |
| In vitro | PF-05231023 is a analog of long-acting fibroblast growth factor 21 [2]. |
| In vivo | Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDsuppresses oxidative-stress-induced inflammation in photoreceptors. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDdecreases the variability of retinal NRF2 levels and displays a trend (non-significant) towards increased NRF2 levels in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDdecreases retinal IL-1β mRNA expression in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDenhances cone-specific arrestin4 expression in Akita mice. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZDrestores photoreceptor morphology in Akita mice. Administration of native FGF21 and Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD(3mg/kg or 10mg/kg; subcutaneously twice a week for two weeks) improves glucose tolerance and liver insulin sensitivity in Zucker rats. Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD(10 mg/kg; intraperitoneally injected) reduces retinal inflammation in diabetic mice [3][4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (7.57 mM), Sonication is recommended. DMSO : 125 mg/mL (236.50 mM), Sonication is recommended.
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| Keywords | PROTACLinker | PROTAC Linkers | PROTAC Linker | PF05231023 | PF 05231023 | Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD | Mal-amido-PEG-2-C2-amido-Ph-C2-CO-AZD | MalamidoPEG2C2amidoPhC2COAZD | Mal amido PEG2 C2 amido Ph C2 CO AZD | Inhibitor | inhibit | FGF21-receptor | FGF21 |
| Inhibitors Related | Boc-C16-COOH | Pentaethylene glycol | Amlexanox | Diethylene glycol bis(p-toluenesulfonate) | 6-Maleimidocapronic acid | Ferulic Acid | Fmoc-8-amino-3,6-dioxaoctanoic acid | 11-Aminoundecanoic acid | 1,3-Dibromo-5,5-dimethylhydantoin | 1-Bromo-6-chlorohexane | Formononetin | Pazopanib |
| Related Compound Libraries | Anti-Diabetic Compound Library | Anti-Breast Cancer Compound Library | NO PAINS Compound Library | Clinical Compound Library | Anti-Metabolism Disease Compound Library |