| Name | Luteolin |
| Description | Luteolin (Luteolol) belongs to the flavonoid group of natural products and is a Nrf2 inhibitor, PDE inhibitor. Luteolin has a wide range of biological activities including antitumor, antioxidant, anti-inflammatory, antimicrobial, antiviral, antiallergic, and procoagulant. |
| In vitro | METHODS: ESCC cell lines EC1, EC9706, KYSE30 and KYSE450 were treated with Luteolin (10-80 µM) for 48-72 h. Cell viability was measured using the CCK-8 Assay.
RESULTS: Luteolin inhibited the growth of ESCC cell lines in a dose-dependent manner with IC50 in the range of 20-60 µM. [1]
METHODS: Human cervical cancer cells, HeLa, were treated with Luteolin (5-20 µM) for 48 h. Cell cycle profiles were analyzed using Flow Cytometry.
RESULTS: Luteolin treatment blocked the cell cycle progression of HeLa cells in sub-G1 phase. [2] |
| In vivo | METHODS: To detect anti-tumor activity in vivo, Luteolin (50 mg/kg) was injected intraperitoneally once daily for eighteen days into BALB/C-nu mice bearing ESCC tumor EC1.
RESULTS: The Luteolin treatment group showed a reduction in tumor size and a reduction in total tumor weight of about 65%. [1]
METHODS: To study the effect on intestinal mucositis, Luteolin (3-30 mg/kg in water plus 1% Tween) was administered by gavage or intraperitoneally to irinotecan-induced intestinal mucositis in Swiss mice once a day for fourteen days.
RESULTS: Luteolin prevented irinotecan-induced intestinal damage by reducing weight loss and diarrhea scores as well as attenuating duodenal and colonic shortening. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.7 mg/mL (19.91 mM), suspension.In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 55 mg/mL (192.15 mM), Sonication is recommended.
Ethanol : 3 mg/mL (10.48 mM), Heating is recommended.
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| Keywords | PDE5 | PDE4 | PDE3 | PDE2 | PDE1 | Luteolin | Keap1-Nrf2 | Inhibitor | inhibit | EndogenousMetabolite | Endogenous Metabolite | Autophagy | Apoptosis |
| Inhibitors Related | Sucrose | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Fumaric acid | Tributyrin | Ferulic Acid | Formamide | Paeonol | Glycerol | Thymidine | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library | Tobacco Monomer Library | Antiparasitic Natural Product Library | Natural Product Library for HTS | Bitter Compound library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Active Compound Library | Food as Medicine Compound Library |
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