| CAS: | 88678-31-3 |
| MF: | C18H20N2O2S |
| MW: | 328.43 |
| EINECS: | 000-000-0 |
| Product Categories: | API;Liranaftate;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;88678-31-3 |
| Mol File: | 88678-31-3.mol |
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| Liranaftate Chemical Properties |
| Melting point | 98.5-99.5°C |
| Boiling point | 462.5±55.0 °C(Predicted) |
| density | 1.240±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| pka | 1.24±0.10(Predicted) |
| form | Solid |
| color | Off-White |
| Merck | 14,5515 |
| Uses | Broad-spectrum antifungal |
| Description | Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed. |
| Chemical Properties | White Crystalline Solid |
| Originator | Tosoh (Japan) |
| Uses | A squalene epoxidase inhibitor. Used as an antifungal. |
| Definition | ChEBI: Liranaftate is a member of tetralins. |
| Brand name | Zefnart |
Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Shanghai Affida New Technology Center, located in Fengxian District, Shanghai. The company produces more than 1000 kinds of high-quality products I20 production lines to provide OEM services, as one of the most dynamic industry and trade integrated companies in the Chinese market.our advantage comes from our service, we can provide fast delivery. The average delivery time in peak season is less than 15 working days, and the average delivery time in off-season is less than 1 month. We have successfully transported many chemical raw materials to many countries in the world. Good feedback and repeat orders have supported the growth of our company.independent production lines, we have 20 pharmaceutical raw materials, organic solvents and other raw material production lines. In addition, we also have an API production workshop with independent research and development production lines, as well as an API research and development testing center. We can provide you with sample testing and accept small orders. Supply 99%+ quality chemical products. We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Ouda will be your strong, sincere and reliable partner in China.
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