Chemical & Physical Properties: 
Approaches to treating T2DM, a disease characterized by the dual defect of islet cell dysfunction and insulin resistance, include agents that increase the secretion of insulin by the pancreas (secretagogues), agents that increase the sensitivity of target organs to insulin (sensitizers), and agents that decrease the glucose absorption rate from the gastrointestinal tract.Liraglutide, the GLP-1 receptor agonist to reach the market, possesses a 97% homology to GLP-1 with only two amino acid changes and the addition of a fatty acid side chain. Specifically, the lysine in position 34 has been replaced with an arginine, and the lysine in position 26 has been modified with a C16 acyl chain via a glutamoyl spacer. Liraglutide derives its resistance to DPP-4 degradation from its propensity to form micelles and to bind to albumin. Unlike its predecessor exenatide, which requires two daily subcutaneous injections before the first and last meals of the day, liraglutide is approved as a once-daily treatment regimen and may be used in combination with metformin or a sulfonylurea in patients with insufficient glycemic control with either monotherapy or combined dual therapy. It is also approved in combination with the dual therapy of metformin and a thiazolidinedione in patients with insufficient glycemic control. Liraglutide displayed a binding potency of 61 pM (EC50= 55 pM for GLP-1) for the cloned human GLP-1 receptor.
Packaging & Shipping
FAQ
Q: How to start orders or make payments?A: You can send your requirement here on line,or send your purchase order by email to us, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.
Q: How to confirm the Product Quality before placing orders?A: You can buy samples for some products,and there will be discount for sample, after testing our sample, if all is ok for you, when make bulk order, we can return the sample fee back to you, and you can also send us your requirement for some special item, we can found for you in our local market.
Q: What's your MOQ?A: For the high value product, our MOQ starts from 1g and generally starts from 1kgs. For other low value product, our MOQ starts from 10kg and 100kg.
Q: Is there a discount?A: Different quantity has different discount, for larger quantity, we alway support with better price.
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Company Profile
Hebei Ningnan Trade Co., Ltd. located in Shijiazhuang City, Hebei Province, is a large enterprise specializing in production and R & D. Our company has many years of export experience in this industry and professional logistics distribution.
We have many production lines, including industrial chemicals, pharmaceutical chemicals, chemical raw materials, fine chemicals and customized synthetic products.
We have a professional R & D team. Products are widely used in industry, rubber, textile, pharmaceutical and other industries. Products are exported to Europe, America, Southeast Asia and other countries. New and old customers are welcome to negotiate business.
China
