LGD-4033 NEW

$0.00 1KG

$0.00 5KG

$0.00 25KG

Min. Order1KG
Purity98%~99%
Cas No1165910-22-4
Supply Ability20 T each week
Update time2023-08-23

Shandong Huisheng Import & Export Co., Ltd.

2YR

China

Since2020-11-16

AddressRoom 202-9, Building 1, Evergrande Huafu, Dongying Road, Huaiyin District, Jinan City, Shandong Prov

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Chemical Properties

Product Name	LGD-4033
CAS No	1165910-22-4
EC-No	1806241-263-5
Min. Order	1KG
Purity	98%~99%
Supply Ability	20 T each week
Release date	2023/08/23

we are a supplier of chemical product raw materials. Pharmaceutical intermediates,Peptides, steroid, Testosterone products, Sarm Product,

Caine products, Steroidhormone product . welcome to your inquiry.

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Contact : telegram/skype/we chat/whatsapp ID： +8613176845580 ross@zhongda-biotech.com

Product Name:	LGD-4033
Synonyms:	4-((R)-2-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile(LGD-4033);LGD-4033;4-[(2R)-2-[(1R)-2,2,2-Trifluoro-1-hydroxyethyl]-1-pyrrolidinyl]-2-(trifluoromethyl)benzonitrile;4-((R)-2-((R)-2,2,2-Trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile;LIGANDROL;4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile;lgd 4033 sarms powder lgd-4033 ligandrol;POWDER LGD-4033 LIGANDROL
CAS:	1165910-22-4
MF:	C14H12F6N2O
MW:	338.25
EINECS:	1806241-263-5
Product Categories:	LGD-4033 whatsapp;SARMs(Selective androgen receptor modulator);1165910-22-4
Mol File:	1165910-22-4.mol

LGD-4033 Chemical Properties

Melting point	108 - 111°C
Boiling point	439.9±45.0 °C(Predicted)
density	1.45±0.1 g/cm3(Predicted)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Acetone (Slightly), Chloroform (Slightly, Heated), Methanol (Slightly)
form	A crystalline solid
pka	12.06±0.20(Predicted)
color	White to Pale Beige
Stability:	Hygroscopic
InChI	InChI=1S/C14H12F6N2O/c15-13(16,17)10-6-9(4-3-8(10)7-21)22-5-1-2-11(22)12(23)14(18,19)20/h3-4,6,11-12,23H,1-2,5H2/t11-,12-/m1/s1
InChIKey	OPSIVAKKLQRWKC-VXGBXAGGSA-N
SMILES	C(#N)C1=CC=C(N2CCC[C@@H]2[C@@H](O)C(F)(F)F)C=C1C(F)(F)F

Safety Information

MSDS Information

LGD-4033 Usage And Synthesis

Description	LGD-4033 is a Selective Androgen Receptor Modulator (SARM). SARMs are a class of non-steroidal anabolic agents that bind androgen receptors with high affinity. LGD-4033 has been shown to provide benefits similar to traditional anabolic agents, (e.g., increased muscle mass, fat loss, and improved bone density) but with far fewer side effects (e.g., oily skin, acne, over-conversion to estrogen, etc.). Both men and women may also appreciate improved libido. All of these benefits are achieved without increasing androgen levels. Its anabolic effects are roughly the same or greater than testosterone, even at low doses. Some prescribers will recommend a trial of SARMs for low testosterone levels prior to utilizing testosterone replacement therapy.
Uses	Ligandrol, also known as LGD-4033, is a nonsteroidal oral drug used for the treatment of muscle wasting and osteoporosis in healthy young men.
Biological Activity	LGD-4033 is a potent nonsteroidal selective androgen receptor modulator (SARM) that binds to the androgen receptor with a Ki value of 1 nM. In animal models, LGD-4033 displays robust selectivity for muscle versus prostate tissues, anabolic activity in the muscle, and anti-resorptive and anabolic activity in bone. LGD 4033 has been abused as a performance-enhancing drug and the identification of its in vitro metabolites has been described. This product is intended for research and forensic applications.
Mechanism of action	LGD-4033 works by binding to androgen receptors in muscle and bone tissue and stimulating protein synthesis, thus helping to build muscle and strength, increase bone density, reduce inflammation, and promote tissue healing. In addition, it can also help improve body composition by reducing fat mass while preserving lean muscle mass.
Pharmacokinetics	LGD-4033 functions by enlarging the androgen receptors, selectively. Anabolic effects on muscles and bones occur rather than negatively altering the prostate or glands, which could be caused through the use of steroids. LGD-4033 has recently been engaged in a study with volunteers called Phase 1 Multiple Ascending Dose. It was random,double blind testing phase in which placebo was used.The aim was to verify that the usage of LGD-4033 is safe and easy to use with a dosage not exceeding 22 mg daily.
Side effects	When taken in appropriate doses, most people experience minimal side effects, if any at all. Some users may experience mild headaches, nausea, or lightheadedness, but these are generally mild and go away quickly.
Safety	LGD-4033 was safe, had favorable pharmacokinetic profile, and increased lean body mass even during this short period without change in prostate-specific antigen. Longer randomized trials should evaluate its efficacy in improving physical function and health outcomes in select populations.
Synthesis	11.20 g Aldehyde (4-(2-(formylpyrrolidin-1-yl)-2-(trifluoromethyl)benzonitril )was dissolved in 300 ml dry tetrahydrofuran and 8.36 g CsF was added directly as a solid to the reaction mixture. It was cooled via ice bath to 0°C and stirred for 15 min. Then 25.00 g trimethyl(trifluoromethyl)silane was added via syringe over a period of 40 min. The reaction is stirred for 15 h coming from 0°C to room temperature over this time interval. The reaction solution shifts color from nearly colorless to dark brown. For stopping the reaction, it was diluted with 100 ml saturated ammonium chloride solution and then evaporated. The resulting emulsion was extracted several times with ethyl acetate and the combined phases dried over magnesium sulfate. After evaporation of all volatiles, the intermediate silyl-ether can be obtained as red-brown oil. This intermediate was converted to the final product LGD-4033 without any further purification. The intermediate was diluted with 400 ml tetrahydrofuran and cooled to 0°C. A cooled potassium hydroxide solution (4.76 g in 400 ml water) was mixed with the diluted oil and stirred at 0°C for 2h. After quenching with 300 ml water, the organic solvent was removed via evaporation from the mixture. The remaining brown oil was extracted with dichloromethane and dried over magnesium sulfate, to yield a reddish-brown oil. This crude product was chromatographed on silica gel by using hexane-ethyl acetat (8:2) as an eluent. During purification, different fractions with several product isomers can be collected . The isolated products LGD-4033 were obtained as 8.50 g yellowish oils (61%).
References	The Safety, Pharmacokinetics, and Effects of LGD-4033, a Novel Nonsteroidal Oral, Selective Androgen Receptor Modulator, in Healthy Young Men In vitro metabolism study of a black market product containing SARM LGD-4033 Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing

LGD-4033 Preparation Products And Raw materials

Raw materials

Caesium fluoride-->(Trifluoromethyl)trimethylsilane-->Potassium hydroxide-->Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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Company Profile Introduction

Shandong Huisheng Import & Export Co., Ltd. is located in Jinan city, Shandong Province, is a collection of domestic trade, international trade in one of the diversified services company. Our goal is to provide customers with high quality solutions and one-stop purchasing experience. At present, the company business scope involves five areas: Organic chemical raw materials, inorganic chemical raw materials, fine chemical raw materials, dangerous chemicals and green environmental protection chemical technology project promotion, and we has also established good relations of cooperation with several well-known enterprises and won the strong support of extensive trust from the new and old customers. Products are widely used in automobile, household appliances, office supplies, mobile phone accessories, routers, food, medical and other fields. At present, our business covers 30 countries, and our customers mainly come from Australia, New Zealand, Canada, Germany, France, Poland, South Korea, Russia, Bangladesh, Vietnam, Kazakhstan, India, Ghana, Nigeria, South Africa, Egypt and other more than 30 countries. The company has a sound quality management system and advanced professional equipment, with a positive attitude to meet the changing needs of customers. We take "quality products, quality service, competitive price, timely delivery" as the purpose, looking forward to greater cooperation with overseas customers on the basis of mutual benefit. Our company provides a wide range of products to meet your various needs. Since its inception, the company has always adhered to the "quality first, customer first, reputation first" business policy, wholeheartedly meet the potential needs of our customers. Under the irresistible situation of economic globalization, our company is willing to cooperate sincerely with enterprises around the world to achieve a win-win situation.