| Description | Levamisole Hcl is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives.IC50 value: Target: Levamisole suppresses the production of white blood cells, resulting in neutropenia and agranulocytosis. With the increasing use of levamisole as an adulterant, a number of these complications have been reported among cocaine users [1] [2]. Levamisole reversibly and noncompetitively inhibits most isoforms of alkaline phosphatase (e.g., human liver, bone, kidney, and spleen) except the intestinal and placental isoform [3]. It is thus used as an inhibitor along with substrate to reduce background alkaline phosphatase activity in biomedical assays involving detection signal amplification by intestinal alkaline phosphatase, for example in in situ hybridization or Western blot protocols. It is used to immobilize the nematode C. elegans on glass slides for imaging. |
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| Related Catalog | Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Neurological Disease |
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| Solvent | In Vitro: DMSO : 15.5 mg/mL (64.38 mM; Need ultrasonic and warming) |
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| Solubility | 1 mM4.1537 mL20.7684 mL41.5369 mL5 mM0.8307 mL4.1537 mL8.3074 mL10 mM0.4154 mL2.0768 mL4.1537 mL |
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| Storage | Powder-20°C3 years 4°C2 yearsIn solvent-80°C6 months -20°C1 month |
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| Shipping | Room temperature in continental US; may vary elsewhere |
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| SMILES | [H]Cl.C12=N[C@@H](C3=CC=CC=C3)CN1CCS2 |
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| References | [1]. Centers for Disease Control and Prevention (CDC). Agranulocytosis associated with cocaine use - four States, March 2008-November 2009.MMWR Morb Mortal Wkly Rep. 2009 Dec 18;58(49):1381-5. [2]. Zhu NY, et al. Agranulocytosis after consumption of cocaine adulterated with levamisole. Ann Intern Med. 2009 Feb 17;150(4):287-9. [3]. Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976 Jul;22(7):972-6. |
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