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ChemicalBook Product Catalog Lenaldekar

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Lenaldekar NEW

$89.00 1mg

$126.00 2mg

$197.00 5mg

Min. Order
Purity99.25%
Cas No418800-15-4
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Lenaldekar
CAS No	418800-15-4
EC-No
Min. Order
Purity	99.25%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Lenaldekar
Description	Lenaldekar (LDK) inhibits T-cell expansion and autoimmune encephalomyelitis. Lenaldekar causes dephosphorylation of members of the PI3 kinase/AKT/mTOR pathway and delays sensitive cells in late mitosis.
In vitro	Lenaldekar could inhibit myelin specific T cell responses through the insulin-like growth factor-1 receptor (IGF-1R) pathway. Alteration of this pathway led to marked reduction in T cell proliferation and expansion. Blocking this pathway could account for the observed decreases in clinical signs and inflammatory demyelinating disease, which was accompanied by axonal preservation[3].
In vivo	Relapsing-remitting experimental autoimmune encephalomyelitis was induced through active immunization of SJL/J mice with a myelin proteolipid protein peptide. The therapeutic efficacy of Lenaldekar treatment was evaluated via daily clinical score, cross-sectional ex vivo diffusion basis spectrum imaging examination and histological analysis. Lenaldekar greatly reduced relapse severity and protected white matter integrity in these experimental autoimmune encephalomyelitis mice. Diffusion basis spectrum imaging-derived axial diffusivity, radial diffusivity and restricted diffusion tensor fraction accurately reflected axonal injury, myelin integrity and inflammation-associated cellularity change, respectively[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 55 mg/mL (192.09 mM)
Keywords	Lenaldekar
Inhibitors Related	Ethyl gallate \| Oridonin \| Capivasertib \| Indirubin Derivative E804 \| SKLB-163 \| Scutellarin \| Artemisinin \| Ceritinib \| Honokiol \| 2,3-Butanediol \| AKT Kinase Inhibitor \| Sodium salicylate
Related Compound Libraries	Pain-Related Compound Library \| Bioactive Compound Library \| HIF-1 Signaling Pathway Compound Library \| Kinase Inhibitor Library \| Tyrosine Kinase Inhibitor Library \| Hematonosis Compound Library \| Anti-Obesity Compound Library \| Metabolism Compound Library \| Anti-Aging Compound Library \| Immunology/Inflammation Compound Library \| Bioactive Compounds Library Max \| Anti-Liver Cancer Compound Library

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