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Lefamulin Basic information
Product Name: Lefamulin
Synonyms: Lefamulin;2-[[(1R,2R,4R)-4-Amino-2-hydroxycyclohexyl]thio]acetic acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester;BC 3781;Lefamulin(BC-3781);Acetic acid, 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
CAS: 1061337-51-6
MF: C28H45NO5S
MW: 507.73
EINECS:
Product Categories: API
Mol File: 1061337-51-6.mol
Lefamulin Structure
Lefamulin Chemical Properties
Boiling point 618.6±55.0 °C(Predicted)
density 1.19±0.1 g/cm3(Predicted)
solubility DMF: 16 mg/mL; DMSO: 12 mg/mL; Ethanol: 3 mg/mL; PBS (pH 7.2): 0.25 mg/mL
form A solid
pka 14.45±0.60(Predicted)
Safety Information
MSDS Information
Lefamulin Usage And Synthesis
Uses Lefamulin is an antibiotic medication used in the treatment of adults with community-acquired bacterial pneumonia.
Lefamulin Preparation Products And Raw materials
Raw materials Cyclohexene, 4-isocyanato-, (4R)--->Acetic acid, 2-[[(1R,2R,4R)-2-hydroxy-4-[(2,2,2-trifluoroacetyl)amino]cyclohexyl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester-->1350636-88-2-->tert-butyl N-[(1R)-cyclohex-3-en-1-yl]carbamate-->tert-butyl N-[(1R,3R,4R)-3-hydroxy-4-sulfanylcyclohexyl]carbamate-->TiaMulin Related CoMpound A-->{(1R,2R,4R)-4-[(tert-butoxycarbonyl)-amino]-2-hydroxy-cyclohexyl} benzene-carbothioate-->(R)-(+)-3-CYCLOHEXENECARBOXYLIC ACID-->3-Cyclohexenecarboxylic acid
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