Basic information Description Uses Application status Safety Related Supplier

ChemicalBook Product Catalog API Larotrectinib

1/1

Larotrectinib NEW

$33.00 1mg

$72.00 5mg

$97.00 10mg

Min. Order
Purity100%
Cas No1223403-58-4
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

show more

Chemical Properties

Product Name	Larotrectinib
CAS No	1223403-58-4
EC-No
Min. Order
Purity	100%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Larotrectinib
Description	Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase, demonstrating high selectivity exclusively for the TRK family of receptors (IC50s = 2-20 nM).
Animal Research	Mice were maintained under aseptic conditions.?The care and treatment of experimental animals was in accordance with institutional guidelines.?5 × 10^5 KM12 cells were injected subcutaneously into the dorsal flank area of the mice.?Tumor volume was monitored by direct measurement with calipers and calculated by the formula: length × (width^2)/2.?Following the establishment of tumor and when the tumor size was between 150–200 mm^2, mice were randomly selected to receive diluent, 60 mg/kg/dose or 200 mg/kg/dose of Larotrectinib(LOXO-101).?LOXO-101 was administered by oral gavage once daily for 14 days.?After the last dose, tissue and blood were collected at 3, 6 and 24 hours post-treatment[1].
In vivo	In vivo, Larotrectinib?(60 and 200 mg/kg) reduces tumor growth in a KM12 mouse xenograft model[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 4.6 mg/mL (10.74 mM)
Keywords	Tropomyosin related kinase receptor \| Trk Receptor \| LOXO101 \| LOXO 101 \| Larotrectinib \| Inhibitor \| inhibit \| ARRY470 \| ARRY 470 \| Apoptosis
Inhibitors Related	Stavudine \| 5-Fluorouracil \| Acetylcysteine \| Myricetin \| Dextran sulfate sodium salt (MW 4500-5500) \| Sodium 4-phenylbutyrate \| L-Ascorbic acid \| Metronidazole \| Sorafenib \| Tributyrin \| Salicylic acid \| Oleic acid
Related Compound Libraries	Highly Selective Inhibitor Library \| Bioactive Compound Library \| Tyrosine Kinase Inhibitor Library \| Kinase Inhibitor Library \| EMA Approved Drug Library \| Drug Repurposing Compound Library \| FDA-Approved Kinase Inhibitor Library \| FDA-Approved Drug Library \| Anti-Cancer Approved Drug Library \| Bioactive Compounds Library Max \| Anti-Cancer Active Compound Library \| Anti-Cancer Drug Library

show more

Company Profile Introduction

You may like

Recommended supplier

MSDS|CAS|CAS DataBase|Pricacy|Terms|About Us|New Products| Contact us|Computer Version
Chemical Book