| Name | L-NMMA acetate |
| Description | L-NMMA acetate (Tilarginine acetate) is an inhibitor of nitric oxide synthase of all NOS isoforms (i.e. NOS1, NOS2, and NOS3). The Ki values are 0.18, 0.4, and 6 µM for nNOS, eNOS, and iNOS, respectively. |
| In vitro | L-NMMA selectively inhibits vasodilator responses to endothelium-dependent ACh without affecting responses to endothelium-independent NP and does not alter isoprenaline-induced relaxation. Its inhibitory action remains unaffected by D-arginine but is countered by L-arginine (L-Arg). L-NMMA initiates a concentration-dependent decrease in vasodilation (2Hz) starting at 100 μM, achieving maximum inhibition around 35% at 1 mM. It reduces arteriolar diameter and increases arteriolar tone in a dose-dependent manner with an immediate onset of action. Moreover, L-NMMA significantly enhances NE-induced vasoconstriction. |
| Storage | store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 24.83 mg/mL (100.01 mM), Sonication is recommended.
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| Keywords | Tilarginine Acetate | Tilarginine | NOS | NO Synthase | nNOS | Nitric oxide synthases | Methylarginine Acetate | Methylarginine | L-NMMA Acetate | LNMMA acetate | L-NMMA | L NMMA acetate | iNOS | Inhibitor | inhibit | eNOS |
| Inhibitors Related | Sucrose | Aceglutamide | L-Pyroglutamic acid | Emtricitabine | Levulinic acid | D(+)-Raffinose pentahydrate | D-(+)-Trehalose dihydrate | Glycerol | Thymidine | Gluconate Calcium | Ovalbumins | Chitosan oligosaccharide |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Multi-Target Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Neuroprotective Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
