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ChemicalBook Product Catalog Biochemical Engineering Amino Acids and Derivatives Lysine derivatives L-Lysine hydrochloride

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L-Lysine hydrochloride NEW

$0.20 1000KG

$5.00 1KG

Min. Order1KG
Purity98%
Cas No657-27-2
Supply Abilityg-kg-tons, free sample is available
Update time2024-04-02

Henan Fengda Chemical Co., Ltd

1YR

China

Since2023-02-10

AddressRoom 01, 2288 E05, Building 14, East Henan University, Science and Technology Park, 279 Xisanhuan Ro

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Chemical Properties

Product Name	L-Lysine hydrochloride
CAS No	657-27-2
EC-No
Min. Order	1KG
Purity	98%
Supply Ability	g-kg-tons, free sample is available
Release date	2024/04/02

1. Materials information

Names

Name	L-lysine hydrochloride
Synonym	More Synonyms

L-(+)-Lysine monohydrochloride Biological Activity

Description	L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Endocrinology Natural Products >> Others Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Research Areas >> Infection
In Vivo	L-lysine treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhances antioxidant activity. Pre- or post-treatment with L-lysine leads to significant decreases in the levels of malondialdehyde and nitric oxide, while significant enhancement is observed in the activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase) and glutathione[1]. L-lysine supplementation almost completely ameliorates vascular calcification. Dietary L-lysine strongly suppresses plasma intact parathyroid hormone in adenine rats and supports a proper bone-vascular axis. The conserved orientation of the femoral apatite in group Lys also evidences the bone-protective effects of L-lysine. Dietary L-lysine elevates plasma alanine, proline, arginine, and homoarginine but not lysine[2]. The dose-dependent delay in gastric emptying observed in rats is confirmed in humans with an increase in halftime of gastric emptying of 4 min/g L-lysine. Moreover, a dose-dependent increase in intestinal fluid accumulation is observed (0.4 mL/min/g L-lysine)[3].
Animal Admin	Rats: Nephrocalcinosis in 6-week-old male Wistar rats is induced by continuous injection of rat PTH 1-34 at a dosage of 40 μg/kg per day via an osmotic mini-pump for 50 hours. L-lysine HCl or glycine at a dose of 20 mmol/kg is administered via a gastric tube at 2 hours, 14 hours, 26 hours, and 38 hours after the implantation of the osmotic pump. At the indicated periods, Serum and urinary biochemical parameters, urea nitrogen, albumin, calcium, inorganic phosphate, and magnesium are determined by clinical diagnostic reagents[2]. Mice: Four groups of mice (10 in each group) are assessed. Group I is the control. Animals in groups II-IV are injected intraperitoneally with L-arginine hydrochloride (400 mg/kg body weight [bw]) for 3 days. Group III animals are orally pre-treated with L-lysine(10 mg/kg bw), whereas group IV animals are orally post-treated with L-lysine(10 mg/kg bw). Serum samples are subjected to amylase, lipase, transaminase, and interleukin-6 (IL-6) assays. The pancreas is excised to measure the levels of malondialdehyde, nitric oxide, catalase, superoxide dismutase, reduced glutathione, and glutathione peroxidase[1].
References	[1]. Al-Malki AL, et al. Suppression of acute pancreatitis by L-lysinein mice. BMC Complement Altern Med. 2015 Jun 23;15:193. [2]. Shimomura A, et al. Dietary L-lysineprevents arterial calcification in adenine-induced uremic rats. J Am Soc Nephrol. 2014 Sep;25(9):1954-65. [3]. Baruffol C, et al. L-lysine dose dependently delays gastric emptying and increases intestinal fluid volume in humans and rats. Neurogastroenterol Motil. 2014 Jul;26(7):999-1009.

Chemical & Physical Properties

Boiling Point	311.5ºC at 760 mmHg
Melting Point	263 °C (dec.)(lit.)
Molecular Formula	C6H15ClN2O2
Molecular Weight	182.648
Flash Point	142.2ºC
Exact Mass	182.082199
PSA	89.34000
LogP	1.72990
Water Solubility	65 g/100 mL (20 ºC)

MSDS

L-(+)-Lysine monohydrochloride MSDS(Chinese)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL5650000

CHEMICAL NAME :
Lysine, monohydrochloride, L-

CAS REGISTRY NUMBER :
657-27-2

LAST UPDATED :
199701

DATA ITEMS CITED :
4

MOLECULAR FORMULA :
C6-H14-N2-O2.Cl-H

MOLECULAR WEIGHT :
182.68

WISWESSER LINE NOTATION :
Z4YZVQ &GH -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
10 gm/kg

TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,49,1973

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
4019 mg/kg

TOXIC EFFECTS :
Behavioral - coma Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 58,253,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3664 No. of Facilities: 612 (estimated) No. of Industries: 4 No. of Occupations: 19 No. of Employees: 5509 (estimated) No. of Female Employees: 1728 (estimated)

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R34
Safety Phrases	S26-S36/37/39-S45-S24/25
RIDADR	UN 1789 8/PG 3
WGK Germany	2
RTECS	OL5650000
HS Code	29224100

Synthetic Route

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Customs

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

2. Packaging of materials

For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.

Or smaller package 1kg/bottle, 10kgs/bottle as request.

3. Shipping & Delivery

By Express

Provide door to door service

Suitable for goods under 50kg

Delivery: 3-7 days

Cost: low cost

By Air

Provide airport to airport service

Suitable for goods over 50kg

Delivery: 3-14 days

Cost: high cost

By Sea

Provide seaport to seaport service

Suitable for goods over 100kg

Delivery: 2-45 days

Cost: low cost

4. Contact information

For more details, pls contact us freely.

Email address: Tina@fdachem.com

Mob: 86 15225627621

WhatsApp/Skype/Wechat/LINE: 86 15225627621

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Company Profile Introduction

Henan Fengda Chemical Co., Ltd. is located in the High-tech Development Zone of Henan Province. Specializing in the production and sales of various fine chemical products required for industrial production, including chemical raw materials, organic raw materials, petrochemicals, chemical reagents, solvents, catalysts, and additives, etc.