| Name | L-Kynurenine |
| Description | L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix. |
| In vitro | Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production thereby increasing tumor growth. L-kynurenine (Kyn) is an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype. Kynurenine activates AHR signaling at physiological concentrations in H1L7.5c3 cells and acts as an AHR agonist after a 24-hr exposure by inducing the AHR-regulated luciferase gene in H1L7.5c3 mouse hepatocyte cells. |
| In vivo | Kynurenine expands rat and human arteries by activating Kv7 channels in the vascular smooth muscle, a process that leads to rat hypotension, partially reversible by inhibiting these channels. When L-kynurenine is given one hour before hypoxia-ischemia, it significantly prevents neurological damage in a dose-dependent manner, achieving full protection at 300 mg/kg. Additionally, this dosage inhibits the activation of c-fos in the cerebral cortex. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (240.14 mM), Sonication is recommended.
0.5M HCL : 50 mg/mL
H2O : 4 mg/mL (at 20°C)
|
| Keywords | L-Kynurenine | LKynurenine | L Kynurenine | Kynurenine | Inhibitor | inhibit | Endogenous Metabolite | Aryl Hydrocarbon Receptor | AhR |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Oleamide | Glycerol | Thymidine | Naringin | Oleic acid | 3-Indoleacetic acid | Oxalic acid dihydrate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Natural Product Library | Microbial Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Human Endogenous Metabolite Library | Bioactive Compounds Library Max | Gut Microbial Metabolite Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
United States
