| Name | L-DABA hydrobromide |
| Description | L-DABA hydrobromide (L-2,4-Diaminobutyric acid hydrobromide) is a potent GABA transaminase inhibitor with antitumor and anticonvulsant activity for the study of neurological disorders. |
| In vitro | Incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C irreversibly and completely damages tumor cells. The cell-destructive effect caused by L-DABA hydrobromide is likely a result of osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA hydrobromide. Concomitant incubation with L-alanine and L-methionine can abolish the harmful effect of L-DABA hydrobromide[1]. Kinetic studies indicate that L-DABA hydrobromide is a non-linear, non-competitive inhibitor of GABA transaminase activity. The elevation of GABA levels induced by L-DABA hydrobromide parallels the inhibition of GABA transaminase activity[2]. L-2,4-Diaminobutyric acid, an amino acid analogue, produces a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA hydrobromide necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line[2]. |
| In vivo | Treatment with L-DABA hydrobromide leads to a 43.4% reduction in tumor growth[1]. In vivo, L-DABA hydrobromide more effectively inhibits GABA transaminase than it does in vitro[3]. |
| Storage | keep away from moisture | Shipping with blue ice. |
| Solubility Information | DMSO : 1.99 mg/mL (10 mM), Sonication is recommended.
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| Keywords | L-2,4-Diaminobutyric acid Hydrobromide | L-DABA Hydrobromide |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Oleamide | Glycerol | Thymidine | Naringin | Salicylic acid | Oxalic acid dihydrate |
| Related Compound Libraries | Bioactive Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
