| 名称 | L-Cysteinesulfinic acid monohydrate |
| 描述 | L-Cysteinesulfinic acid monohydrate is a potent agonist at rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively [1]. |
| 体外活性 | L-Cysteinesulfinic acid (monohydrate) serves as an innate activator for the phospholipase D (PLD)-linked metabotropic excitatory amino acids (EAA) receptor, selectively triggering the PLD-associated mechanism. When applied to hippocampal slices, 1 mM concentrations of L-CSA (monohydrate) significantly enhance PLD activity, unlike similar doses of L-glutamate, L-aspartate, and L-HCA, which show no effect. Furthermore, L-CSA (monohydrate) prompts a dose-responsive elevation in PLD activity in these slices, even when iGluR antagonists are present, with the potency around an EC50 of 500 uM. Notably, the response to 1 mM L-CSA (monohydrate) in augmenting PLD activity remains unaltered by 1 uM tetrodotoxin, indicating that the effect is not reliant on an increase in neuronal activity[1]. |
| 存储条件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 120 mg/mL (701.06 mM), Sonication is recommended.
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| 关键字 | L Cysteinesulfinic acid monohydrate | LCysteinesulfinic acid monohydrate | Metabotropic glutamate receptors | Inhibitor | inhibit | L-Cysteinesulfinic acid Monohydrate | L-Cysteinesulfinic acid | mGluR |
| 相关产品 | IDRA-21 | Decanoic Acid | L-Cysteic acid monohydrate | Evans blue | L-Glutamine | Direct Blue 1 | L-Glutamic acid monosodium salt | Piracetam | O-Phospho-L-serine | Memantine hydrochloride |
| 相关库 | 经典已知活性库 | 神经退行性疾病化合物库 | 神经信号分子库 | 膜蛋白靶向化合物库 | 神经递质受体化合物库 | 已知活性化合物库 | 小鼠代谢化合物库 |
United States
