| Name | L-Canavanine sulfate |
| Description | L-Canavanine sulfate is a selective inducible NO synthase inhibitor. |
| Cell Research | The following cancer cells grown in arginine-rich and arginine-free media were employed: HeLa, Hep G2 and SK-HEP-1. Drug combination experiment used a method based on the median-effect principle and mass-action law[1]. |
| In vitro | L-Canavanine sulfate,which is hardly toxic alone, potentiated the cytotoxicity of VIN and PTX in HeLa and hepatocellular carcinoma cells[1]. |
| In vivo | Intravenous infusion of L-canavanine (100 mg/kg), a selective inhibitor of inducible NO synthase in vitro, 60 min and 180 min after lipopolysaccharide challenge, produced an increase in mean arterial pressure and reversed the lipopolysaccharide induced hypotension. However, in lipopolysaccharide challenged animals protected from hypotension by administration of L-canavanine (60 min post challenge), intravenous infusion of NG-nitro-L-arginine methyl ester at 180 min post challenge caused an immediate rise in mean arterial pressure, followed by a rapid fall in blood pressure and heart rate, and sudden death. In contrast, a second dose of L-canavanine at 180 min post challenge maintained blood pressure for the duration of the experiment. Inhibition of both constitutive and inducible NO synthase during endotoxaemia is lethal[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL (364.63 mM), Sonication and heating are recommended.
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| Keywords | NOSynthase | NOS | NO synthesis | NO Synthase | Nitric oxide synthases | L-Canavanine Sulfate | LCanavanine sulfate | L-Canavanine | L Canavanine sulfate | Inhibitor | inhibit |
| Inhibitors Related | Aminoguanidine hydrochloride | L-NAME hydrochloride | Chondroitin sulfate | Mifepristone | 2,4-Diamino-6-hydroxypyrimidine | S-Methylisothiourea sulfate | L-Arginine | Nitroarginine | NLRP3-IN-2 | Ethyl cinnamate | Methylene Blue | L-Arginine hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Natural Product Library | Inhibitor Library | Neuroprotective Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Food as Medicine Compound Library |
United States
