| CAS: | 4350-09-8 |
| MF: | C11H12N2O3 |
| MW: | 220.22 |
| EINECS: | 224-411-1 |
| Product Categories: | Amino Acids;Biochemistry;Biological-modified Amino Acids;Indoles;Tryptophans;Natural Plant Extract;Pharmaceutical Raw Materials;Indoles and derivatives;Tryptophan [Trp, W];Amino acidsPeptide Synthesis;Biochemicals Found in Plants;Nutrition Research;natural product;Inhibitors;Tryptophan Derivatives;Unnatural Amino Acid Derivatives;Amines;Heterocycles;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Metabolites & Impurities;Pharmaceuticals;Amines, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;amino;Other APIs;4350-09-8 |
| Mol File: | 4350-09-8.mol |
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| L-5-Hydroxytryptophan Chemical Properties |
| Melting point | 270 °C (dec.) (lit.) |
| alpha | -32.5 º (c=1,H2O on dry basis) |
| Boiling point | 361.16°C (rough estimate) |
| density | 0.902 g/mL at 25 °C (lit.) |
| refractive index | n20/D 1.4850(lit.) |
| Fp | 175 °F |
| storage temp. | 2-8°C |
| solubility | H2O: 10 mg/mL |
| pka | 2.22±0.10(Predicted) |
| form | solid |
| color | white |
| optical activity | [α]22/D 30°, c = 1 in H2O |
| Water Solubility | Slightly soluble |
| Merck | 14,4847 |
| BRN | 88200 |
| LogP | -0.140 (est) |
| CAS DataBase Reference | 4350-09-8(CAS DataBase Reference) |
| EPA Substance Registry System | L-5-Hydroxytryptophan (4350-09-8) |
| L-5-Hydroxytryptophan Usage And Synthesis |
| Chemical Properties | white to pale grey powder |
| Uses | A labelled metabolite of Tryptophan |
| Uses | 5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan |
| Uses | 5-Hydroxy-L-tryptophan has been used:
to inject experimental mice for serotonin detection as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis
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| Definition | ChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion. |
| General Description | Colorless to pale pink crystals. |
| Air & Water Reactions | L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble . |
| Reactivity Profile | L-5-Hydroxytryptophan reacts with bases. . |
| Fire Hazard | Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible. |
| Biochem/physiol Actions | Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache. |
| Purification Methods | Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.] |
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Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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