| 名称 | Kurarinone |
| 描述 | Kurarinone is a flavonoid extracted from the shrub Sophora flavescens, which has anti-tumor, estrogenic and anti-inflammatory activities, and also has a strong inhibitory effect on immune responses. |
| 体外活性 | METHODS: To test the cytotoxicity of kurarinone on HMC3 cells, we treated HMC3 cells with different concentrations of kurarinone (10, 20, 40 or 80 μM) for 24 hours.
RESULTS HMC3 cell viability was reduced after treatment with 80 μM Kur.
METHODS: Two human small cell lung cancer (SCLC) cell lines H1688 and H146, and an immortalized bronchial epithelial cell line BEAS-2B were treated with different concentrations of kurarinone (3.125 ~ 50 μM), and the IC50 was determined.
RESULTS The IC50 values of kurarinone against H1688, H146 and BEAS-2B cells were 12.5±4.7, 30.4±5.1 and 55.8±4.9 μM respectively. [3] |
| 体内活性 | METHODS: Arthritis was reproduced in DBA/1 mice by inducing bovine type II collagen (CII) as a collagen-induced arthritis (CIA) model. After establishment of CIA, kurarinone (100 mg/kg/day) was administered orally from day 21 to day 42, and severity was determined based on symptom scoring scales and histopathology. ELISA and flow cytometry were used to detect the cytokine levels, anti-cii antibody levels, and T cell proliferation and lineage in the draining lymph nodes, respectively.
RESULTS kurarinone treatment reduced the severity of arthritis in CIA mice and reduced the levels of pro-inflammatory cytokines TNF-α, IL-6, IFN-γ and IL-17A in serum and foot tissue. [1] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (125.42 mM)
|
| 关键字 | Kurarinone | inhibit | Inhibitor |
| 相关产品 | Lidocaine | Nifuroxazide | Diethylmaleate | Resveratrol | Glucosamine | sodium lauroyl-α-hydroxyethyl sulfonate | Lidocaine hydrochloride | Apremilast | 5-Aminosalicylic Acid | Indole-3-carbinol | Lenalidomide | Diallyl disulfide |
| 相关库 | 抗癌天然产物库 | 黄酮类天然产物库 | 经典已知活性库 | 中药单体化合物库 | 植物来源化合物库 | 天然产物库 | 高通量筛选天然产物库 | 抗衰老化合物库 | 已知活性化合物库 | 抗癌活性化合物库 |
United States
