| Name | KR-32568 |
| Description | KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM) with potent cardioprotective effects. At a concentration of 10 μM, it restored cardiac systolic function in an isolated ischemic rat heart model. Additionally, KR-32568 (0.3 mg/kg) reduced myocardial infarction size in a rat model of ischemia and reperfusion injury. |
| In vitro | KR-32568 (10 nM-1 μM) inhibited NHE-1-mediated platelet swelling induced by intracellular acidification in rabbit platelet-rich plasma in a concentration-dependent manner, with an IC50 value of 24 nM.[1] |
| In vivo | KR-32568 (0.1-1.0 mg/kg; i.v.; once) exerts effective cardioprotective effects in rats, such as reducing infarct size and significantly reducing the total number of premature ventricular contractions.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 90 mg/mL (344.5 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (12.63 mM), Sonication is recommended.
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| Keywords | SodiumChannel | Sodium Channel | Na+/H+-exchanger (NHE) | KR-32568 | KR32568 | KR 32568 |
| Inhibitors Related | Phenytoin sodium | Procaine | Lidocaine Hydrochloride hydrate | Lidocaine | Safinamide | Valproic Acid | Lidocaine hydrochloride | L-Aspartic aicd sodium | Mebeverine hydrochloride | Amitriptyline hydrochloride | Riluzole | Benzocaine |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Sodium Channel Targeted Library | Neuroprotective Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Ion Channel Targeted Library | Anti-Cancer Compound Library |