名称 | Kisspeptin-10, human (TFA)(374675-21-5,FREE) |
描述 | Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression |
体外活性 | KP-10-treatment significantly increased the expression of osteogenic genes, including mRNA and protein levels of BMP2, in C3H10T1/2 cells.?Moreover, KP-10 induced BMP2-luc activity and increased phosphorylation of Smad1/5/9.?In addition, NFATc4 specifically mediated KP-10-induced BMP2 gene expression.?However, KP-10 treatment did not induce expression of the BMP2 and Runx2 genes in GPR54-/- cells.?To examine whether KP-10 induced secretion of BMP2 to the culture medium, we used the conditioned-medium (C.M) of KP-10 treated medium on C3H10T1/2 cells.?Dlx5 and Runx2 expressions were higher in GPR54-/- cells treated with C.M than in those treated with KP-10[1]. |
存储条件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | H2O : 4 mg/mL (2.82 mM), Sonication is recommended.
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关键字 | Kisspeptin 10, human (TFA)(374675 21 5,FREE) | Kisspeptin10, human (TFA)(374675215,FREE) | Kisspeptin-10, human (TFA)(374675-21-5,FREE) |
相关产品 | Vincamine | Monomethyl fumarate | Questiomycin A | Benzyl nicotinate | TUG-1375 |
相关库 | 经典已知活性库 | 多肽分子库 | 内分泌激素分子库 | NO PAINS 化合物库 | 已知活性化合物库 | GPCR靶点分子库 |