| 名称 | Kartogenin |
| 描述 | Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. |
| 细胞实验 | For the cell viability assay, fibroblasts are seeded on six-well plates, followed by Kartogenin or DMSO treatment. According to the manufacturer's instructions, cell viability and viability are assessed by AlamarBlue assay.(Only for Reference) |
| 体外活性 | Kartogenin promotes type I collagen synthesis in dermal fibroblasts by activating the Smad4/Smad5 pathway, without exhibiting significant cytotoxicity on the activity, morphology, and survival of fibroblasts. Additionally, by enhancing the nuclear localization of CBFβ, Kartogenin induces differentiation of hMSCs into chondrocytes and protects articular chondrocytes. |
| 体内活性 | Kartogenin at a concentration of 100 nM stimulates collagen synthesis in the dermis of mice. Additionally, it promotes the growth of skeletal limbs and the development of synovial joints in mice. Concentrations of 10 μM and 100 μM Kartogenin respectively enhance cartilage repair in mouse models of osteoarthritis (OA) induced by collagenase VII and surgically. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : <1 mg/mL
DMSO : 63 mg/mL (198.52 mM)
Ethanol : 18 mg/mL (56.72 mM), Heating is recommended.
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| 关键字 | Inhibitor | TGF-beta/Smad | stem | Kartogenin | chondrocytes | human | differentiation | inhibit | mesenchymal | Transforming growth factor beta | cells | osteoarthritis |
| 相关产品 | Monocrotaline | SB-431542 | DMH-1 | RepSox | Chromenone 1 | LY-364947 | BMP signaling agonist sb4 | Pirfenidone | A 83-01 | Galunisertib | Alantolactone | Pentabromophenol |
| 相关库 | 细胞重编程化合物库 | 经典已知活性库 | 细胞因子抑制剂库 | HIF-1化合物库 | 血管生成库 | 干细胞分化化合物库 | NO PAINS 化合物库 | 已知活性化合物库 | 抗肝癌化合物库 | 转录因子库 |
United States
