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ChemicalBook Product Catalog Biochemical Engineering Natural Products Kakkalide

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Kakkalide NEW

$197.00 1mg

$417.00 5mg

$622.00 10mg

Min. Order
Purity99.1%
Cas No58274-56-9
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Kakkalide
CAS No	58274-56-9
EC-No
Min. Order
Purity	99.1%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Kakkalide
Description	Kakkalide is a potent lactate dehydrogenase (LDH) inhibitor, it has anti-inflammatory effects.
In vitro	Human umbilical vein endothelial cells (HUVEC) were stimulated with 100 μmol/L palmitate (PA) for 30 min and the effects of 30 min pretreatment with 0.1-10 μmol/L Kakkalide on reactive oxygen species (ROS)-associated inflammation in cells were evaluated by western blot analysis and reverse transcription-polymerase chain reaction. Furthermore, we investigated the biomodulation of insulin signaling by Kakkalide along the insulin receptor substrate (IRS)-1/Akt/endothelial nitric oxide synthase (eNOS) pathway. We also determined the effects of 30 min pretreatment with 0.1-10 μmol/L Kakkalide on insulin-mediated endothelium-dependent vasodilation of rat aorta in vitro following stimulation with 100 μmol/L PA. Kakkalide inhibited ROS overproduction and effectively restored mitochondrial membrane potential, demonstrating its chemoprotection of mitochondrial function. In addition, Kakkalide inhibited ROS-associated inflammation in the endothelium by inhibiting tumor necrosis factor-α± and interleukin-6 production and gene expression, as well as suppressing the phosphorylation of c-Jun N-terminal kinase and IκB kinase β/nuclear factor-κB. Inflammation impaired insulin phosphatidylinositol 3-kinase (PI3K) signaling and reduced insulin-mediated NO production in endothelial cells. Kakkalide facilitated PI3K signaling by positively regulating serine/tyrosine phosphorylation of IRS-1.
Storage	store at low temperature,keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 10 mM
Keywords	Inhibitor \| Kakkalide \| inhibit
Inhibitors Related	Disulfiram \| Methotrexate \| Rotenone \| Mycophenolate Mofetil \| Ribavirin \| 4-Diethylaminobenzaldehyde \| Benzyl alcohol \| Isomalt \| Isoniazid \| Ivosidenib
Related Compound Libraries	Flavonoid Natural Product Library \| Traditional Chinese Medicine Monomer Library \| Bioactive Compound Library \| Rare Natural Product Library \| Selected Plant-Sourced Compound Library \| Anti-Inflammatory Traditional Chinese Medicine Compound Library \| Natural Product Library for HTS \| Bioactive Compounds Library Max \| Ancient Chinese Classical Formulas Compound Library \| Food as Medicine Compound Library

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