| Name | Kaempferol 3-neohesperidoside |
| Description | Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid compound, exhibits an insulinomimetic effect on the rat soleus muscle. |
| In vitro | A stimulatory effect of Kaempferol 3-neohesperidoside ( 1) on glucose uptake (35% and 21%) was observed when the rat soleus muscle was incubated with 1 and 100 nM of this flavonoid glycoside, respectively. The concentration-response curve of insulin showed a stimulatory effect at 3.5 and 7.0 nM (42% and 50%) on glucose uptake when compared with the control group. The effect of Kaempferol 3-neohesperidoside on glucose uptake was completely nullified by pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and RO318220, an inhibitor of protein kinase C (PKC). However, no significant change occurred on glucose uptake stimulated by Kaempferol 3-neohesperidoside when muscles were pretreated with PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and cycloheximide, an inhibitor of protein synthesis. Kaempferol 3-neohesperidoside and insulin (7 nM) did not show a synergistic effect on glucose uptake. Additionally, 100 mg/kg of Kaempferol 3-neohesperidoside by oral gavage was able to increase glycogen content in the muscle[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/ml (92.51 mM)
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| Keywords | inhibit | Kaempferol 3-neohesperidoside | Inhibitor | Kaempferol 3neohesperidoside | Kaempferol 3 neohesperidoside |
| Inhibitors Related | Myricetin | Erucic acid | Lidocaine | CHIR-99021 | 4-Chloro-2'-bromoacetophenone | Lidocaine hydrochloride | 3-Methyladenine | Isoprenaline hydrochloride | Trametinib | Quercetin | Quercetin Dihydrate | Apilimod |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Pain-Related Compound Library | Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Neuroprotective Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
