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ChemicalBook Product Catalog JTV-519

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JTV-519 NEW

$55.00 1mg

$112.00 5mg

$157.00 10mg

Min. Order
Purity99.8%
Cas No1038410-88-6
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	JTV-519
CAS No	1038410-88-6
EC-No
Min. Order
Purity	99.8%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	JTV-519
Description	JTV-519 is a Ca2+-dependent blocker and prevents abnormal Ca(2+) leak from the sarcoplasmic reticulum in the ischemic heart and skeletal muscle (SkM) by stabilizing the ryanodine receptors.
In vitro	In isolated cardiac and SkM SR microsomes, K201 slowed the rate of SR Ca(2+) loading, suggesting potential SERCA block and/or RyR agonism. K201 displayed Ca(2+)-dependent inhibition of SERCA-dependent ATPase activity, which was measured in microsomes incubated with 200, 2, and 0.25 µM Ca(2+) and with the half-maximal K201 inhibitory doses (IC50) estimated at 130, 19, and 9 µM (cardiac muscle) and 104, 13, and 5 µM (SkM SR). K201 (≥5 µM) increased RyR1-mediated Ca(2+) release from SkM microsomes. Maximal K201 doses at 80 µM produced ∼37% of the increase in SkM SR Ca(2+) release observed with the RyR agonist caffeine. K201 (≥5 µM) increased the open probability (Po) of very active ('high-activity') RyR1 of SkM reconstituted into bilayers, but it had no effect on 'low-activity' channels. Likewise, K201 activated cardiac RyR2 under systolic Ca(2+) conditions (∼5 µM; channels at Po ∼0.3) but not under diastolic Ca(2+) conditions (∼100 nM; Po < 0.01)[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 25 mg/mL (54.22 mM)
Keywords	K201 \| JTV519
Inhibitors Related	Nisoldipine \| Nimodipine \| Diltiazem hydrochloride \| Levetiracetam \| L-Ascorbic acid \| Lanthanum(III) chloride heptahydrate \| Ethyl cinnamate \| 1-Octanol \| 2-Nitrobenzoic acid \| 1,2,4-Trihydroxybenzene \| Methyl homoveratrate \| Otilonium bromide
Related Compound Libraries	Pain-Related Compound Library \| Bioactive Compound Library \| Neuronal Signaling Compound Library \| Membrane Protein-targeted Compound Library \| Anti-Cancer Clinical Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| Neuroprotective Compound Library \| Bioactive Compounds Library Max \| Ion Channel Targeted Library \| Anti-Cancer Compound Library \| Anti-Cancer Drug Library

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Company Profile Introduction

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