| Name | Isovaleramide |
| Description | Isovaleramide (3-Methylbutanamide) is an anticonvulsant molecule isolated from Valeriana pavonii, which can inhibit the liver alcohol dehydrogenases. |
| In vitro | Research on the reproductive toxicity of Isovaleramide in mice, rats, and rabbits demonstrates its potential to be significantly lower than that of VPA. Oral administration of Isovaleramide at a dose of 100 mg/kg resulted in a 90% protection index against maximal electroshock seizures in mice. |
| In vivo | At a concentration of 0.15%, Isovaleramide induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3. In in vitro assays, 300 μM Isovaleramide inhibits 42% of 3H-FNZ binding to its target site. At concentrations up to 1000 μM, Isovaleramide does not affect the binding and uptake assays of various neurotransmitters in vitro, suggesting that its mechanism of action does not involve direct receptor-mediated effects. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 16 mg/mL (158.18 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 75 mg/mL (741.47 mM), Sonication is recommended.
|
| Keywords | Isovaleramide | Inhibitor | inhibit | Alcohol DHO |
| Inhibitors Related | Disulfiram | Methotrexate | Rotenone | Mycophenolate Mofetil | Ribavirin | 4-Diethylaminobenzaldehyde | Mycophenolic acid | Methotrexate disodium | Benzyl alcohol | Isomalt | Isoniazid | Ivosidenib |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Metabolism Compound Library | Drug Repurposing Compound Library | Natural Product Library | Tobacco Monomer Library | NO PAINS Compound Library | Natural Product Library for HTS | Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library |
United States
