| Name | Isoimperatorin |
| Description | Isoimperatorin is an anti-inflammatory agent, exhibits significant inhibitory effects on acetylcholinesterase (AChE). |
| In vitro | The ethanol extract from Notopterygium incisum rhizomes displays significant nematicidal activity against nematodes Bursaphelenchus xylophilus and Meloidogyne incognita, discovered during a search for new agrochemicals from Chinese medicinal herbs. Four components—Columbianetin, Falcarindiol, Falcarinol, and Isoimperatorin—were isolated and identified from the extract via bioactivity-guided fractionation. Isoimperatorin exhibited notable efficacy with an LC50 value of 21.83 μg/mL against B. xylophilus. Under 15 min UV light exposure, Falcarindiol, Falcarinol, and Isoimperatorin showed nearly quintuple toxicity increase toward southern root-knot nematodes compared to dark conditions, whereas Columbianetin's toxicity doubled. Additionally, Isoimperatorin has been proven to have insecticidal properties against various insects, including the cabbage aphid (Brevicoryne brassicae). It has been found in the active fraction of Angelica dahurica (AD) extract and is frequently used as the internal standard (IS) in assays. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 10 mg/mL (37 mM), Sonication is recommended.
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| Keywords | Isoimperatorin | Inhibitor | inhibit | Cholinesterase (ChE) | Bacterial | AChE |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Miao medicine Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |
United States
