| Name | IRAK4-IN-1 |
| Description | IRAK4-IN-1 is an interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. |
| Animal Research | In the TLR driven in vivo model, female Lewis rats are dosed with either vehicle or IRAK4-IN-1 (Compound 23; 3, 10, 30, and 100 mg/kg; p.o.) dosed at 1 h prior to stimulation with Resiquimod, R848 (5 mg/kg, IP). At 1.5 h post R848 stimulation, blood samples are obtained from the animals and cytokine levels are measured. |
| In vitro | The in vitro metabolic stability profile of IRAK4-IN-1 was assessed, yielding an EC50 of 2300 nM in rat whole blood (RWB). |
| In vivo | Oral pharmacokinetic analyses of IRAK4-IN-1 indicate that it possesses a high bioavailability of 73%, along with low plasma clearance (Clp=22 mL/min/kg), which culminates in a stable half-life of 1.3 hours. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1 mg/mL (2.96 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.96 mM), Sonication is recommended.
H2O : < 0.1 mg/mL (insoluble)
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| Keywords | IRAK4-IN-1 | IRAK-4-IN-1 | IRAK4IN1 | IRAK4 IN 1 | IRAK-4 | IRAK | Interleukin-1 receptor associated kinase | Inhibitor | inhibit | IL-1R associated kinase |
| Inhibitors Related | IRAK inhibitor 2 | IRAK inhibitor 1 | IRAK-1-4 Inhibitor I | IRAK-4 protein kinase inhibitor 2 | ANTHRAQUINONE-2-CARBOXYLIC ACID | Thalidomide 4-fluoride | Ginsenoside Rb1 | GLPG2534 | Zabedosertib | Zimlovisertib | AS-2444697 | JH-X-119-01 |
| Related Compound Libraries | Highly Selective Inhibitor Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Inhibitor Library | NO PAINS Compound Library | Anti-Fibrosis Compound Library | Anti-Prostate Cancer Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library |
United States
