IR813
Modify Date: 2024-01-07 17:52:57
 IR813 structure | Common Name | IR813 |
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| CAS Number | 134127-48-3 | Molecular Weight | 755.40600 |
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| Density | N/A | Boiling Point | N/A |
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| Molecular Formula | C47H47ClN2O3S | Melting Point | N/A |
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| MSDS | N/A | Flash Point | N/A |
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Use of IR813
IR 813 tosylate is a near-infrared (NIR) fluorescent dye (λex=815 nm, λem=840 nm) and can be used for visualizing regional lymph nodes in mice[1]. |
Names
| Name | 1h-benz[e]indolium, 2-[2-[2-chloro-3-[(1,3-dihydro-1,1,3-trimethyl-2h-benz[e]indol-2-ylidene)ethylidene]-1-cyclohexen-1-yl]ethenyl]-1,1,3-trimethyl-, salt with 4-methylbenzenesulfonic acid (1:1) |
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| Synonym | More Synonyms |
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IR813 Biological Activity
| Description | IR 813 tosylate is a near-infrared (NIR) fluorescent dye (λex=815 nm, λem=840 nm) and can be used for visualizing regional lymph nodes in mice[1]. |
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| Related Catalog | Research Areas >> Others Signaling Pathways >> Others >> Others |
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| In Vitro | IR 813 (17.3 μM, 2 h) tosylate induces a 31.4% hemolysis in red blood cells[1]. IR 813 (5.9 μM, 24 h) tosylate induces 50% cell death in MRC-5 cells[1]. |
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| In Vivo | IR 813 tosylate displays a maximum fluorescence intensity at 4 h postinjection together with a rapid extravasation, when being used for visualizing regional lymph nodes in mice[1]. Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[1]. 1. Animal: Ten-week-old female Balb/cOlaAnN mice are kept in a 12 h light/dark cycle to reduce tissue autofluorescence in the NIR region, and had access to food and water ad libitum. 2. Dose: A single dose 5.1 nmol of IR 813 dye (20 μL of 0.173 mg/mL, dissolved in a PEG-400/ethanol/water=3:2:5, v/v/v solution) is subcutaneous injected in the right anterior paw of mice. 3. Imaging: Using the Fluobeam700 NIR imaging system to perform in vivo optical imaging (739 nm excitation light (3.5 mW), 750 nm long-pass emission cutoff filter).Fluorescence intensity in the axillary lymph node (ALN) is recorded for 1 week (5 min, 1 h, 4 h, 24 h, 7 days). 4. Data analysis: Semiquantitative data is obtained from the fluorescence images using ImageJ 1.44 software. |
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Chemical & Physical Properties
| Molecular Formula | C47H47ClN2O3S |
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| Molecular Weight | 755.40600 |
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| Exact Mass | 754.30000 |
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| PSA | 71.83000 |
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| LogP | 12.47360 |
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Company Profile
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![4-methylbenzenesulfonate,1,2,3,3-tetramethylbenzo[e]indol-3-ium structure](https://image.chemsrc.com/caspic/490/141914-99-0.png)
![N-[(3-(Anilinomethylene)-2-chloro-1-cyclohexen-1-yl)methylene]aniline (hydrochloride) structure](https://image.chemsrc.com/caspic/300/63857-00-1.png)
