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ChemicalBook Product Catalog API Respiratory Drugs Asthma drugs Ipratropium Bromide

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Ipratropium Bromide NEW

$38.00 50mg

$48.00 100mg

$82.00 200mg

Min. Order
Purity99.94%
Cas No22254-24-6
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Ipratropium Bromide
CAS No	22254-24-6
EC-No
Min. Order
Purity	99.94%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	Ipratropium Bromide
Description	Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema.
In vitro	Ipratropium bromide combined with Formoterol partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity. [1] Ipratropium bromide (1 nM) significantly increases [Ca(2+)](i), decreases forward scatter and increases annexin-V-binding. Ipratropium bromide treatment is followed by slight but significant increase of hemolysis. Ipratropium bromide triggers suicidal erythrocyte death or eryptosis, an effect mainly due to stimulation of Ca(2+)-entry. [2]
In vivo	Ipratropium dry powder inhalation (DPI) at a dose of 2400 mg/horse is an effective bronchodilator in these horses at rest but it has little effect on the airway calibre during the recovery period. [3] Ipratropium significantly attenuates the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium treated rats. Ipratropium bromide partially protects the lungs against the inflammation by reducing neutrophilic infiltration. [4] Ipratropium is an antagonist for pre-junctional muscarinic inhibitory receptors on pulmonary parasympathetic nerves and also confirms its potent antagonist actions on post-junctional muscarinic receptors in the airway smooth muscle in the guinea-pig. [5] Ipratropium decreases the maximal change in pleural pressure during tidal breathing (delta Pplmax) and pulmonary resistance (RL) and increases dynamic compliance (Cdyn) in horse. [6]
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	H2O : 201.3 mM DMSO : 50 mg/mL (121.25 mM)
Keywords	Ipratropium \| asthma \| chronic obstructive pulmonary disease \| inhibit \| Inhibitor \| Sch-1000 \| Sch1000 \| Ipratropium Bromide \| mAChR \| Muscarinic acetylcholine receptor \| ischaemia/reperfusion \| I/R
Inhibitors Related	Adiphenine hydrochloride \| Ribavirin \| Choline chloride \| Propoxur
Related Compound Libraries	Bioactive Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Membrane Protein-targeted Compound Library \| Drug Repurposing Compound Library \| FDA-Approved Drug Library \| Bioactive Compounds Library Max

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