| Name | Inosine |
| Description | Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties. |
| In vitro | Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] |
| In vivo | The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 55 mg/mL (205.05 mM)
H2O : 43 mg/mL (160.3 mM)
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| Keywords | Inhibitor | INO495 | metabolism | inhibit | human | P1 receptor | antinociceptive | Inosine | adenosine | disease | INO-495 | Adenosine Receptor | metabolite | neuroprotective | nucleoside | antihyperalgesic | NSC20262 | NSC-20262 | Endogenous Metabolite | immunomodulatory | antiallodynic | Parkinson's |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Oleamide | Glycerol | Thymidine | Naringin |
| Related Compound Libraries | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Natural Product Library for HTS | Anti-Cancer Approved Drug Library | Human Endogenous Metabolite Library | Anti-Aging Compound Library | Ancient Chinese Classical Formulas Compound Library |
United States
