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ChemicalBook Product Catalog Imidazole ketone erastin

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Imidazole ketone erastin NEW

$71.00 1mg

$98.00 2mg

$172.00 5mg

Min. Order
Purity99.87%
Cas No1801530-11-9
Supply Ability10g
Update time2024-11-16

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	Imidazole ketone erastin
CAS No	1801530-11-9
EC-No
Min. Order
Purity	99.87%
Supply Ability	10g
Release date	2024/11/16

Product Introduction

Bioactivity

名称	Imidazole ketone erastin
描述	Imidazole ketone erastin (IKE) is an ferroptosis inducer with inhibitory effects on system Xc-cystine/glutamate transporter proteins. Imidazole ketone erastin has antitumor activity and induces glutathione depletion and lipid peroxidation.
体外活性	METHODS: Human astrocytoma cells CCF-STTG1 were incubated with Imidazole ketone erastin for 2 h. Glutamate released into the medium was detected using glutamate oxidase, horseradish peroxidase, and Amplex UltraRed fluorimetric assay. RESULTS: The IC50 for system xc- inhibition by Imidazole ketone erastin was 30 nM. [1] METHODS: 18 DLBCL cell lines were treated with Imidazole ketone erastin (0.0001-100 µM) for 24 h. Cell viability was measured using the Cell Titor-Glo luminescent cell viability test. RESULTS: DLBCL cell lines showed different sensitivities to Imidazole ketone erastin inhibition. 7 cell lines with IC50 <100 nM were categorized as sensitive; 5 cell lines with IC50 >10 µM were categorized as resistant; and 6 cell lines with IC50 between 100 nM and 10 µM were categorized as moderately resistant. [2]
体内活性	METHODS: To detect anti-tumor activity in vivo, Imidazole ketone erastin (23-40 mg/kg, 5% DMSO in HBSS at pH 4) was injected intraperitoneally into NCG mice harboring human diffuse histiocytic lymphoma SUDHL6 once daily for thirteen days. RESULTS: Imidazole ketone erastin inhibited tumor growth in vivo. [2] METHODS: To test the antitumor activity in vivo, Imidazole ketone erastin (40 mg/kg every two days) and liproxstatin-1 (10 mg/kg once a day) were intraperitoneally injected into C57BL/6 mice with the hepatocellular carcinoma tumor Hepa1-6 for ten days on either a control (Met+) or a methionine-free (Met-) diet. Met-) diet. RESULTS: In mice receiving the control diet, Imidazole ketone erastin treatment effectively reduced tumor growth, and this effect was completely blocked by liproxtatin-1. However, in mice receiving a methionine-free diet, Imidazole ketone erastin treatment failed to inhibit tumor growth. [3]
存储条件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 18.33 mg/mL (27.98 mM), Sonication is recommended.
关键字	Imidazole ketone erastin
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