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ChemicalBook Product Catalog ILK-IN-2

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ILK-IN-2 NEW

$40.00 1mg

$98.00 5mg

$130.00 10mg

Min. Order
Purity99.31%
Cas No1333146-24-9
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	ILK-IN-2
CAS No	1333146-24-9
EC-No
Min. Order
Purity	99.31%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	ILK-IN-2
Description	ILK-IN-2 (OSU-T315) is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.
In vitro	ILK-IN-25 exhibited high in vitro potency against a panel of prostate and breast cancer cell lines (IC(50), 1-2.5 μM), while normal epithelial cells were unaffected. ILK-IN-25 facilitated the dephosphorylation of Akt at Ser-473 and other ILK targets, including glycogen synthase kinase-3β and myosin light chain. Moreover, ILK-IN-25 suppressed the expression of the transcription/translation factor YB-1 and its targets HER2 and EGFR in PC-3 cells, which could be rescued by the stable expression of constitutively active ILK [1]. The cytotoxicity of ILK-IN-25 in normal B or T cells was significantly lower (LC50 > 10 μM). ILK-IN-25 had the effect of dose-dependent cytotoxicity toward 2 CLL-derived cell lines, Mec-1 and OSU-CLL (LC50 of 2-3 μM in both) after 24-hour treatment [2].
In vivo	Athymic nude mice bearing established subcutaneous PC-3 tumors were treated with oral ILK-IN-25 once daily at 25 and 50 mg/kg or vehicle control. The daily administration of ILK-IN-25 at both doses was well tolerated. Treatment with oral ILK-IN-25 in either dose resulted in significant suppression of tumor growth relative to the vehicle control after 35 days of treatment (48% and 62% suppression for 25 and 50 mg/kg, respectively) [1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 9 mg/mL (16.87 mM)
Keywords	Integrin \| inhibit \| ILK IN 2 \| ILK-IN-2 \| ILKIN2 \| Inhibitor \| OSU-T-315 \| OSU-T 315
Inhibitors Related	K34c hydrochloride \| E7820 \| Arg-Gly-Asp TFA (99896-85-2(free base)) \| Tirofiban hydrochloride monohydrate \| Lifitegrast \| Elarofiban TFA \| Cyclo(-RGDfK) \| Tirofiban \| Bestatin hydrochloride \| RO0270608 \| ICAM-1-IN-1 \| Gantofiban
Related Compound Libraries	Bioactive Compound Library \| Kinase Inhibitor Library \| Inhibitor Library \| Orally Active Compound Library \| Bioactive Compounds Library Max \| Cytoskeletal Signaling Pathway Compound Library \| Anti-COVID-19 Compound Library

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