名称 | IHVR-17028 |
描述 | IHVR-17028 is a potent broad-spectrum ERα-glucosidase I (α-glucosidase? I) inhibitor with IC50 of 0.24 μM and antiviral activity. IHVR-17028 inhibited BVDV, TCRV and DENV, and EC50 values were 0.4 μM, 0.26 μM and 0.3 μM, respectively. IHVR-17028 can be used to study infectious diseases. |
体外活性 | IHVR-17028 demonstrates potent antiviral activity against bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), and DENV (serotype 2, New Guinea C) with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively, in virus yield reduction assays. Furthermore, IHVR-17028 exhibits high cell viability with IC50 values exceeding 500 μM in MDBK, Huh7.5, and BHK cells, as determined by MTT assays.[1] |
体内活性 | In rats, during pharmacokinetic analysis, IHVR17028 (75 mg/kg, oral gavage) demonstrates a C max value of 0.18 μg/ml. The T max value is 1.56 hours, and after PO administration, the F% value is 12%. The T 1/2 value is 0.88 hours after iv administration[1].
In a mouse model of lethal MARV infection, IHVR-17028 treatment (25-50 mg/kg, oral gavage) one day before virus challenging exhibits significant protection.[1] |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 30 mg/mL (69.99 mM)
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关键字 | IHVR-17028 | IHVR17028 | IHVR 17028 |
相关产品 | Rifampicin | Acetylcysteine | α-Vitamin E | AEBSF hydrochloride | Nitazoxanide | Curcumin | N-Acetylneuraminic acid | Naringenin | (E)-3-(4-Methoxyphenyl)acrylic acid | Salcomine | Crystal Violet | β-Cyclodextrin |
相关库 | 经典已知活性库 | 激酶抑制剂库 | 抗病毒库 | 抑制剂库 | 已知活性化合物库 |