| Name | IFN alpha-IFNAR-IN-1 hydrochloride |
| Description | IFN alpha-IFNAR-IN-1 hydrochloride is an inhibitor of the interaction between IFN-α and IFNAR, effectively inhibiting MVA-induced IFN-α responses by BM-pDCs with an IC50 of 2-8 μM. |
| In vitro | IFN alpha-IFNAR-IN-1 hydrochloride inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 hydrochloride specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 hydrochloride exerts immunosuppressive activity by the direct interaction with IFN-α[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 16 mg/mL (50.66 mM), Sonication is recommended.
DMSO : 95 mg/mL (300.77 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (10.45 mM), Sonication is recommended.
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| Keywords | Interferon-α/β receptor | Interferon-alpha/beta receptor | Inhibitor | inhibit | IFNAR | IFN α-IFNAR-IN-1 Hydrochloride | IFN alpha-IFNAR-IN-1 Hydrochloride | IFN alphaIFNARIN1 hydrochloride | IFN alpha IFNAR IN 1 hydrochloride | IFN a-IFNAR-IN-1 Hydrochloride |
| Inhibitors Related | 2',3'-cGAMP sodium | Feeblin | Deucravacitinib | RO8191 | DC-Chol hydrochloride | Icariside I | Allura Red AC | Cridanimod | Actarit | CCCP | 2'-Deoxy-2'-fluorouridine | TNF/IFNγ-IN-1 |
| Related Compound Libraries | Bioactive Compound Library | Cytokine Inhibitor Library | Inhibitor Library | PPI Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
United States
