| Name | Hyperforin |
| Description | Hyperforin, a natural product from Hypericum, is commonly used as an antidepressant and also has neurological, inflammatory, antimicrobial, antitumor and antiangiogenic effects. Hyperforin acts as a monoamine reuptake inhibitor (MRI) in vitro, including serotonin, norepinephrine, dopamine, GABA, and glutamate, with an IC 50 of ≈0.1 μg/mL. Hyperforin is also capable of inducing the cytochrome P450 enzymes, CYP3A4 and CYP2C9, through binding to and activation of the pregnane X receptor. Hyperforin is capable of activating TRPC6 channels by binding to a specific motif. |
| In vitro | Methods: Hyperforin (0.1, 1, 10 μM) was used to treat TNF α-stimulated HaCaT cells, and the expression of related proteins was determined by Western Blot.
Results: Hyperforin at a dose of 10 μM reduced the expression of p-p38, p-ERK, p-JNK, and p-STAT3 in HaCaT cells. [3] |
| In vivo | Methods: Hyperforin (5 mg/kg, once a day, 7 days) was used to treat IMQ-induced psoriasis-like mouse models to observe whether it improved the skin lesions of psoriasis.
Results: Hyperforin significantly improved skin lesions throughout the treatment period, while inhibiting the infiltration of CD3+ T cells and downregulating the expression of Il1, Il6, Il23, Il17a, Il22, and antimicrobial peptides (AMPs) in skin lesions. [3] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Hyperforin | COX-1 | 5HTReceptor | 5HT Receptor | 5-HT |
| Inhibitors Related | Rosiglitazone | 2,4,6-Tri-tert-butylphenol | Caffeic Acid | L-Ascorbic acid | Camphor | Probenecid | L-Phenylalanine | trans-Cinnamaldehyde | Ethyl cinnamate | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid |
United States
