| Name | Hypaconitine |
| Description | Hypaconitine, an active and highly toxic constituent derived from Aconitum species, possesses anti-inflammatory activity and is widely used to treat rheumatism. |
| Animal Research | Adult Wistar rats were orally administered?Hypaconitine?(0.23, 0.69, 2.07 mg/kg per day), liquiritin (20 mg/kg per day), or?Hypaconitine?(2.07 mg/kg per day) plus liquiritin (20 mg/kg per day) for seven consecutive days. The mRNA expression levels of CaM and Cx43 in rat myocardial tissue were determined by real-time quantitative PCR. The protein contents of CaM and phosphorylated Cx43 (Ser368) were determined by Western blot |
| In vitro | Hypaconitine (0.08-2 microM) depressed the nerve-evoked twitch tension, without affecting the contraction evoked by stimulation of the muscle,At the concentrations of hypaconitine (up to 5 microM)that depressed the nerve-evoked twitch tension, the resting membrane potential of the muscle cells was unchanged. Hypaconitine (0.1-2 microM) blocked the end-plate potential (epp), without affecting the amplitude of the miniature epp (mepp). The quantal content of end-plate potentials was decreased by these agents in parallel with the decrement in amplitude. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (81.21 mM)
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| Keywords | Inhibitor | TNFR | TNF Receptor | Hypaconitine | inhibit | Tumor Necrosis Factor Receptor |
| Inhibitors Related | Tebuconazole | 1-Ethynylnaphthalene | Apigenin | Fenofibrate | Glucosamine | 1-Aminobenzotriazole | Apremilast | Naringin | Naringenin | Lenalidomide | Tauroursodeoxycholate | Fisetin |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Bioactive Compound Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Bioactive Compounds Library Max |
United States
