Name | Hypaconitine |
Description | Hypaconitine, an active and highly toxic constituent derived from Aconitum species, possesses anti-inflammatory activity and is widely used to treat rheumatism. |
Animal Research | Adult Wistar rats were orally administered?Hypaconitine?(0.23, 0.69, 2.07 mg/kg per day), liquiritin (20 mg/kg per day), or?Hypaconitine?(2.07 mg/kg per day) plus liquiritin (20 mg/kg per day) for seven consecutive days. The mRNA expression levels of CaM and Cx43 in rat myocardial tissue were determined by real-time quantitative PCR. The protein contents of CaM and phosphorylated Cx43 (Ser368) were determined by Western blot |
In vitro | Hypaconitine (0.08-2 microM) depressed the nerve-evoked twitch tension, without affecting the contraction evoked by stimulation of the muscle,At the concentrations of hypaconitine (up to 5 microM)that depressed the nerve-evoked twitch tension, the resting membrane potential of the muscle cells was unchanged. Hypaconitine (0.1-2 microM) blocked the end-plate potential (epp), without affecting the amplitude of the miniature epp (mepp). The quantal content of end-plate potentials was decreased by these agents in parallel with the decrement in amplitude. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 50 mg/mL (81.21 mM)
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Keywords | Inhibitor | TNFR | TNF Receptor | Hypaconitine | inhibit | Tumor Necrosis Factor Receptor |
Inhibitors Related | Tebuconazole | 1-Ethynylnaphthalene | Apigenin | Fenofibrate | Glucosamine | 1-Aminobenzotriazole | Apremilast | Naringin | Naringenin | Lenalidomide | Tauroursodeoxycholate | Fisetin |
Related Compound Libraries | 中药单体化合物库 | 经典已知活性库 | 生物碱类天然产物库 | 植物来源化合物库 | 天然产物库 | 中药抗炎分子库 | 高通量筛选天然产物库 | 抗衰老化合物库 | 已知活性化合物库 |