| Name | Hycanthone |
| Description | Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal. Hycanthone is a DNA intercalator that inhibits RNA synthesis and DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits APE1 via direct protein binding(KD: 10 nM). |
| In vitro | Hycanthone at 20 mg/mL or more is progressively more detrimental to cell viability. Compared to that of controls, results show that increased concentrations of Hycanthone, ranging from 0.1 to 10 μg/mL, progressively decreases viral interferon yields as much as 73% [2]. |
| In vivo | Male worms treated with Hycanthone display signs of possible partial recovery from the initial low levels of incorporation. After treatment with Hycanthone, the incorporation of tritiated thymidine into TCA-precipitable material of adult sensitive worms undergo a progressive decrease. Immature worms are totally unaffected by Hycanthone at all times tested. In the first four days after treatment, incorporation of tritiated leucine by drug-sensitive worms treated with Hycanthone is inhibited by 40 to 50%. 7 days after Hycanthone treatment, both ribosomal RNA species are reduced by at least 80% with respect to untreated worms, with some indication of a possible accumulation of heavier precursor molecules [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : < 0.1 mg/mL (insoluble)
DMSO : 18 mg/mL (50.49 mM), Sonication is recommended.
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| Keywords | APE1 | inhibit | DNA/RNA Synthesis | acid | intercalator | Topoisomerase | Lucanthone | anti-schistosomal | nucleic | apurinic | endonuclease-1 | biosynthesis | Inhibitor | Hycanthone | thioxanthenone | Parasite |
| Inhibitors Related | Rifampicin | 5-Fluorouracil | Kaempferol | Procaine | Hydroxychloroquine | Guanidine hydrochloride | Metronidazole | Nitazoxanide | Doxycycline | N-Nitrosodiethylamine | Benzyl benzoate | Thymidine |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Aging Compound Library | Anti-Cancer Active Compound Library |
United States
