| Name | Homo-PROTAC cereblon degrader 1 |
| Description | Homo-PROTAC cereblon degrader 1 is a highly potent and efficient cereblon (CRBN) degrader with only minimal effects on IKZF1 and IKZF3. |
| In vitro | Homo-PROTAC cereblon degrader 1 (0-1 μM, 16 hours) effectively reduces Cereblon protein levels in the multiple myeloma cell line NCI-H929. Experimental results indicate that the effect is observed at a concentration of 10 nM after 16-hour incubation. The degradation efficiency reaches its peak at concentrations between 100 nM and 1 μM. However, when the concentration is further increased to 100 μM, the degradation of Cereblon is completely inhibited [1].
When MM1S cells were treated with Homo-PROTAC cereblon degrader 1 (100 nM, 0-24 hours), cereblon protein levels decreased within 15 minutes and peaked at 6 hours [1].
The effects of homo-PROTAC cerebrone degrader 1 (0-10 μM, 4 days) on the proliferation of palomidomide-sensitive multiple myeloma cell lines MM1S, NCI-H929, LP-1, KMS27, and RPMI 8226 were investigated. The results showed that Homo-PROTAC cereblon degrader 1 had little effect on the proliferation of the cells at concentrations of ≤1 μM [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (302.74 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (7.57 mM), Sonication is recommended.
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| Keywords | PROTACs | Inhibitor | inhibit | Homo-PROTAC cereblon degrader 1 | HomoPROTAC cereblon degrader 1 | Homo PROTAC cereblon degrader 1 | Cereblon |
| Inhibitors Related | ARV-393 HCl | ACBI1 | ARV-471 | CCT367766 | dBET6 | Dbet57 | dBET1 | ARV-825 | Lenalidomide | AU-15330 | β-NF-JQ1 | C004019 |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
United States
