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ChemicalBook Product Catalog HA130

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HA130 NEW

$33.00 2mg

$52.00 5mg

$85.00 10mg

Min. Order
Purity≥95%
Cas No1229652-21-4
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	HA130
CAS No	1229652-21-4
EC-No
Min. Order
Purity	≥95%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	HA130
Description	HA130 is a selective ATX (autotaxin) inhibitor.
Kinase Assay	Saturation, association, and dissociation binding studies are performed for [3H]Vilanterol to determine receptor binding kinetics at the β2-AR (equilibrium dissociation constant (KD), total number of receptors (Bmax), association rate (kon), and dissociation rate (koff) are calculated). For saturation binding, membranes (in a volume of 1.4 mL to avoid ligand depletion) are incubated with increasing concentrations of [3H]Vilanterol (~0.01-1.3 nM) for 5 h before filtration. For association binding, membranes are incubated with different concentrations of [3H]Vilanterol (~0.1-1.9 nM) for varying incubation times up to 1 h before filtration. For dissociation binding, membranes are preincubated for 1 h with a fixed concentration of [3H]Vilanterol (~1.1 nM) before dissociation is initiated by a 1:20 dilution in binding buffer (containing 10 μM cold Vilanterol) and then incubated for varying times up to 8 h before filtration. Saturation binding is also completed for [3H]CGP12177 (increasing concentrations of ~0.01-2.8 nM) in the same format as described above for [3H]Vilanterol. To determine the affinity of β2-AR agonists and antagonists, competition binding displacement studies are completed in which membranes are incubated with a fixed concentration of [3H]Vilanterol (~0.2 nM) and increasing concentrations of unlabeled agonist/antagonist for 5 h before filtration. All competition binding displacement studies are completed in the presence of 100 μM Gpp(NH)p to ensure that binding curves are monophasic[1].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 46.33 mg/mL (100 mM)
Keywords	inhibit \| HA-130 \| HA 130 \| Phosphodiesterase (PDE) \| Inhibitor \| HA130
Inhibitors Related	Theophylline monohydrate \| Diphylline \| Acefylline \| Roflumilast \| Theobromine \| Apremilast \| Isoprenaline hydrochloride \| Indomethacin \| Icariin \| Theophylline \| Vardenafil hydrochloride \| Doxofylline
Related Compound Libraries	Bioactive Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Anti-Alzheimer's Disease Compound Library \| Inhibitor Library \| Anti-Cardiovascular Disease Compound Library \| Metabolism Compound Library \| Bioactive Compounds Library Max \| Covalent Inhibitor Library \| Fluorochemical Library \| Anti-Metabolism Disease Compound Library

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