| Name | HA-1004 dihydrochloride |
| Description | HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein |
| In vivo | HA-1004, was shown to be a potent inhibitor of two cyclic nucleotide-dependent protein kinases, cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein kinase and the Ki values were 1.4 and 2.3 microM, respectively.?HA-1004 relaxed rabbit aortic strips contracted by various agonists and with similar ED50 values.?Phenotolamine, propranolol and atropine did not affect this HA-1004-induced relaxation, thereby suggesting that this compound does not act through these membrane receptor associated mechanisms.?HA-1004 shifted the dose-response curve for CaCl2 to the right in a competitive manner in depolarized rabbit renal arterial strips.?This compound also relaxed the A-23187 and phenylephrine-induced contractions elicited in Ca++-free solution.?HA-1004 exerts its action at the intracellular or submembranal level.?This vasodilator has little effect on actomyosin adenosine triphosphatase and Ca++-calmodulin-dependent myosin light chain kinase.?Studies using its derivatives with various lengths of alkyl chain (C0-C6) indicated that the potencies of these compounds, as vasorelaxants, correlated well with their potential to inhibit cyclic nucleotide-dependent protein kinase.?HA-1004 should be a useful tool for investigating in smooth muscle, regulatory mechanism(s) by second messengers, cyclic AMP and cyclic GMP[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | PKC | PKA | HA-1004 Dihydrochloride | HA1004 dihydrochloride | HA1004 Dihydrochloride | HA-1004 | HA1004 | HA 1004 dihydrochloride | HA 1004 Dihydrochloride | HA 1004 | CalciumChannel | calcium channel | Calcium Channel |
| Inhibitors Related | TBHQ | 2,4,6-Tri-tert-butylphenol | L-Ascorbic acid | α-Vitamin E | L-Phenylalanine | Lidocaine hydrochloride | Ethyl cinnamate | L-Ascorbic acid sodium salt | Tauroursodeoxycholate | 2-Nitrobenzoic acid | Isovaleric acid | β-Glycerophosphate disodium salt hydrate |
| Related Compound Libraries | Pain-Related Compound Library | Tyrosine Kinase Inhibitor Library | Kinase Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Ion Channel Targeted Library |
United States
