| Name | H-Tyr(3-I)-OH |
| Description | H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) is an inhibitor of tyrosine hydroxylase (Ki = 0.39 M) and an intermediate in the synthesis of thyroid hormones |
| Animal Research | Twenty mice were infused with H-Tyr(3-I)-OH into the dorsal striata.?Mice were anesthetized with ketamine (50 mg/kg IP) and xylazine (5mg/kg IP,) and placed in a David Kopf stereotaxic apparatus.?Vehicle and H-Tyr(3-I)-OH solution (0, 1 and 10μM H-Tyr(3-I)-OH dissolved in 0.9% NaCl with 0.001% acetic acid) was slowly injected (5 μl volume) with a blunted 30-gauge cannula at the following coordinates of the left dorsal striata with respect to bregma: AP= +0.86, L= +1.6, and V= -3.5 mm. |
| In vivo | 3-iodo-L-tyrosine, at high concentration, is able to induce the intracellular aggregation of αSyn, and death of TH-positive neurons. These phenomena are considered as hallmarks of PD |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 10 mM, Sonication is recommended.
DMSO : Insoluble
|
| Keywords | tyrosine hydroxylase | thyroid hormone | metabolite | Inhibitor | inhibit | Human Endogenous Metabolite | H-Tyr(3-I)-OH | HTyr(3I)OH | H Tyr(3 I) OH | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Acetaminophen | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
| Related Compound Libraries | Bioactive Compound Library | Natural Product Library | Inhibitor Library | NO PAINS Compound Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | Human Endogenous Metabolite Library | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Mouse Metabolite Compound Library | Human Metabolite Library |
United States
