| 名称 | Gypenoside L |
| 描述 | Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory activity. |
| 体外活性 | gypenoside L (Gyp-L), a saponin isolated from Gynostemma pentaphyllum, on cancer cell growth.?We found that Gyp-L increased the SA-β-galactosidase activity, promoted the production of senescence-associated secretory cytokines, and inhibited cell proliferation of human liver and esophageal cancer cells.?Moreover, Gyp-L caused cell cycle arrest at S phase, and activated senescence-related cell cycle inhibitor proteins (p21 and p27) and their upstream regulators.?In addition, Gyp-L activated p38 and ERK MAPK pathways and NF-κB pathway to induce senescence.?Consistently, adding chemical inhibitors efficiently counteracted the Gyp-L-mediated senescence, growth inhibition, and cell cycle arrest in cancer cells.?Furthermore, treatment with Gyp-L, enhanced the cytotoxicity of clinic therapeutic drugs, including 5-fluorouracil and cisplatin, on cancer cells.?Overall, these results indicate that Gyp-L inhibits proliferation of cancer cells by inducing senescence and renders cancer cells more sensitive to chemotherapy[1]. |
| 存储条件 | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 166.67 mg/mL (208.07 mM), Sonication is recommended.
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| 关键字 | Gypenoside L | MAPK | Extracellular signal regulated kinases | NF-κB | Nuclear factor-κB | saponin | anti-tumor | Nuclear factor-kappaB | inhibit | ERK | anti-inflammatory | Inhibitor | p38 MAPK | cytokines | p38 |
| 相关产品 | TBHQ | Acetylcysteine | L-Ascorbic acid | Glucosamine | Lidocaine hydrochloride | Lycopene | Indole-3-carbinol | 1-Octanol | Diallyl disulfide |
| 相关库 | 铜死亡化合物库 | 铁死亡化合物库 | 抗结直肠癌中药单体化合物库 | 稀有天然产物库 | 钙通道分子库 | NO PAINS 化合物库 | 高通量筛选天然产物库 | MAPK 抑制剂库 |
United States
