Name | GW9508 |
Description | GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner. |
In vivo | In MIN6 cells, GW9508 stimulates insulin secretion in a dose-dependent manner and enhances insulin secretion mediated by KCl. In rat β-cells, GW9508 induces hyperpolarization and the opening of KATP channels. In HaCaT cells, GW9508 inhibits the expression of IL-11, IL-24, and IL-33 induced by TNF-α and IFN-γ. Additionally, in normal human epidermal keratinocytes, GW9508 suppresses the production of CCL5 and CXCL10. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | Ethanol : 34.7 mg/mL (100 mM) DMSO : 40 mg/mL (115.14 mM), Sonication is recommended.
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Keywords | TNF-α | KcsA | insulin | GPR40 | glucose-sensitive | Potassium Channel | GPR120 | Free Fatty Acid Receptor | KATP | FFA1 | anti-inflammatory | CCL5 | CXCL10 | GW9508 | Inhibitor | inhibit | GW-9508 | IFN-γ | FFAR | anti-atherosclerotic |
Inhibitors Related | Minoxidil sulfate | Quinine | Monomethyl fumarate | (±)-Naringenin | Tolbutamide | Tetraethylammonium bromide | Halothane | Butamben | Benzyl nicotinate | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Indapamide |
Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | GPCR Compound Library | Ion Channel Targeted Library |