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ChemicalBook Product Catalog GW 4064

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GW 4064 NEW

$46.00 5mg

$76.00 10mg

$142.00 25mg

Min. Order
Purity99.94%
Cas No278779-30-9
Supply Ability10g
Update time2024-11-19

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

5YR

United States

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Chemical Properties

Product Name	GW 4064
CAS No	278779-30-9
EC-No
Min. Order
Purity	99.94%
Supply Ability	10g
Release date	2024/11/19

Product Introduction

Bioactivity

Name	GW 4064
Description	GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
Cell Research	GW 4064 is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Mouse liver cells (BNL CL.2) are maintained in a humidified incubator under 5% CO2 at 37°C in Dulbecco's Modified Eagle's Medium (DMEM) supplemented with 10% fetal bovine serum (FBS) and 1% Penicillin/Streptomycin. When cells are divided into six-well plates and reach ~90% confluence, sub-confluent cells are washed three times with phosphate buffered saline (PBS) and replaced with serum-free DMEM supplemented with 1% fatty acid-free BSA. Oleic acid (final concentration 500 μM) and GW4064 at various concentrations are added and incubated for 24 h. Cells are then fixed with 4% formaldehyde for Oil Red O staining or harvested for protein and western blot analysis[2].
In vitro	In Fisher rats, oral administration of GW 4064 (ED50 = 20 mg/kg) effectively reduces serum triglycerides.
In vivo	In CV-1 cells transfected with mouse FXR expression vectors (EC50=80 nM) and in CV-1 cells transfected with human FXR expression vectors (EC50=90 nM), GW 4064 functions as a selective non-steroidal FXR agonist, effectively exerting agonistic effects.
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 50 mg/mL (92.11 mM) Ethanol : 5.4 mg/mL (10 mM)
Keywords	Inhibitor \| FXR \| Autophagy \| GW 4064 \| inhibit \| NR1H4 \| GW-4064 \| GW4064
Inhibitors Related	Stavudine \| Xylitol \| Myricetin \| Sodium 4-phenylbutyrate \| Hydroxychloroquine \| Guanidine hydrochloride \| Taurine \| Curcumin \| Oxyresveratrol \| Paeonol \| Naringin \| Gefitinib
Related Compound Libraries	Nuclear Receptor Compound Library \| Bioactive Compound Library \| ReFRAME Related Library \| Autophagy Compound Library \| NO PAINS Compound Library \| Metabolism Compound Library \| Lipid Metabolism Compound Library \| Bioactive Compounds Library Max \| Bioactive Lipid Compound Library \| Anti-Metabolism Disease Compound Library

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