| 名称 | Guanabenz Acetate |
| 描述 | Guanabenz Acetate (Wytensin) is a specific agonist of adrenergic receptor. The pEC50 for α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor is 8.25, 7.01 and ~5, respectively. |
| 体外活性 | Guanabenz inhibits the response of vascular contractions in various processes and initiates normal sympathetic nerve discharge, while also antagonizing the stimulation of the sympathetic nervous system. Administering 0.5 mg/kg of Guanabenz intravenously in anesthetized hypertensive rats and dogs leads to a reduction in blood pressure and heart rate. Moreover, an intravenous injection of 0.1 mg/kg Guanabenz in anesthetized dogs initially causes an increase in blood pressure due to the action of the sympathetic nervous system, followed by a decrease in cardiac output, contractility, and heart rate. |
| 体内活性 | In mammalian MovS6 cells, 10 μM of Guanabenz facilitates the complete clearance of PrPSc. Additionally, in HEK293 cells transfected with rat inducible nitric oxide synthase (nNOS), 30 μM Guanabenz induces a time-dependent reduction in nNOS activity, with a Ki value of 1 μM. In HEK 293 cells, treatment with 50 μM Guanabenz for 3 hours results in approximately a 75% decrease in the accumulation of nitrites and nitrates within the cells. Furthermore, treatment with 100 μM Guanabenz for 24 hours leads to about a 35% reduction in the quantity of inducible nitric oxide synthase protein detected by immunological methods. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 40 mg/mL (137.4 mM), Sonication is recommended.
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| 关键字 | Adrenergic Receptor | BR750 | Guanabenz | Beta Receptor | Guanabenz Acetate | Wy8678 Acetate | Inhibitor | Wy-8678 | BR 750 | inhibit | Wy8678 | Wy 8678 |
| 相关产品 | Octopamine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride |
| 相关库 | 神经退行性疾病化合物库 | 经典已知活性库 | 药物功能重定位化合物库 | FDA 上市药物库 | 抗癌上市药物库 |
United States
