Product Details
Gonarelin acetate is secreted by the sagging brain in the body, and can stimulate the anterior pituitary gland to secrete gonadotrophins FSH and LH. LH can promote the synthesis and secretion of androgens in the male testicular interstitium. The dual action of LH and FSH can promote ovarian synthesis and secretion of estrogen. Continuous application of this product has a biphasic effect on the pituitary: it can initially promote the secretion of LH and FSH from the anterior pituitary, and increase the level of LH, FSH and sex hormones in plasma; In the long run, it can lead to the decrease of LHRH receptors in the pituitary gland, prevent the secretion of LH in the pituitary gland, thus blocking the synthesis and secretion of testosterone, and achieve the same effect as the removal of testis. In women, it blocks the production and secretion of estrogen to achieve the same effect as ovariectomy. Therefore, it can treat hormone-dependent prostate cancer and breast cancer, and it is also suitable for endometriosis. This synthetic product is mainly used as an ovulation promoting drug to treat infertility and primary ovarian insufficiency caused by hypothalamic amenorrhea, especially for clomiphene. It is also used in children with cryptorchidism and androgen excess, pituitary tumor. The peak value was 3 minutes after intravenous injection. t1/2 is about 6min and is excreted after rapid metabolism through the kidney.
China
