GLYCIDYL ISOPROPYL ETHER NEW

• DATA ITEMS CITED :

• 44

• MOLECULAR FORMULA :

• C6-H12-O2

• MOLECULAR WEIGHT :

• 116.18

• WISWESSER LINE NOTATION :

• T3OTJ B1OY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• Standard Draize test

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• TYPE OF TEST :

• Standard Draize test

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• TYPE OF TEST :

• Standard Draize test

• ROUTE OF EXPOSURE :

• Administration into the eye

• SPECIES OBSERVED :

• Rodent - rabbit

• TYPE OF TEST :

• Standard Draize test

• ROUTE OF EXPOSURE :

• Administration into the eye

• SPECIES OBSERVED :

• Rodent - rabbit

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 4200 mg/kg

• TOXIC EFFECTS :

• Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Behavioral - ataxia

• TYPE OF TEST :

• LC50 - Lethal concentration, 50 percent kill

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 1100 ppm/8H

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - other changes Liver - other changes

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 1300 mg/kg

• TOXIC EFFECTS :

• Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Behavioral - ataxia

• TYPE OF TEST :

• LC50 - Lethal concentration, 50 percent kill

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 1500 ppm/4H

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - other changes Liver - other changes

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Administration onto the skin

• SPECIES OBSERVED :

• Rodent - rabbit

• DOSE/DURATION :

• 9650 mg/kg

• TOXIC EFFECTS :

• Lungs, Thorax, or Respiration - acute pulmonary edema

• TYPE OF TEST :

• TCLo - Lowest published toxic concentration

• ROUTE OF EXPOSURE :

• Inhalation

• SPECIES OBSERVED :

• Rodent - rat

• DOSE/DURATION :

• 400 ppm/7H/10W-I

• TOXIC EFFECTS :

• Nutritional and Gross Metabolic - weight loss or decreased weight gain

• TYPE OF TEST :

• Specific locus test

• TYPE OF TEST :

• Heritable translocation test

MUTATION DATA

• TYPE OF TEST :

• Sister chromatid exchange

• TEST SYSTEM :

• Rodent - hamster Lung

• REFERENCE :

• MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991 *** REVIEWS *** ACGIH TLV-STEL 356 mg/m3 (75 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 238 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 50 ppm (240 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,142,1971 OSHA PEL (Gen Indu):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 50 ppm (240 mg/m3);STEL 75 ppm (360 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (238 mg/m3);STEL 75 ppm (356 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-FINLAND:STEL 50 ppm (240 mg/m3) JAN 1993 OEL-FRANCE:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-THE NETHERLANDS JAN 1993 OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (240 mg/m3);STEL 100 ppm (480 mg/m3) JAN 1993 OEL-TURKEY:TWA 30 ppm (240 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 50 ppm (240 mg/m3);STEL 75 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ISOPROPYL GLYCIDYL ETHER-air:CL 50 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992